卒中后中枢神经痛的研究进展

发布时间：2018-02-28 05:15

本文关键词： 脑卒中中枢性神经痛综述　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：卒中后中枢神经痛(CPSP)是卒中后疼痛中最常见的一种中枢性神经病理性疼痛,常发生于脑卒中后6个月内。其发生与脑卒中部位有关,在脊髓-丘脑-皮质感觉传导通路上任何部位的脑卒中均可发生CPSP,而且年龄较轻和椎基底动脉系统的脑卒中患者更易发生CPSP。CPSP的发病机制尚不明确,但目前得到广泛关注的是“中枢敏化”和“脱抑制”假说。CPSP的临床表现多样,主要与发病部位有关,但主要特征是疼痛和感觉异常。疼痛呈烧灼、挤压、针刺、寒冷、或撕裂样,可因情绪紧张、寒冷、热度、疲劳或身体运动而加剧,休息后减轻。CPSP的诊断虽有多个诊断标准,但均缺乏特异性,需结合病史、体格检查及影像学资料,并排除其他原因引起的疼痛。CPSP的治疗较困难,可采用药物、神经调控及心理干预的综合治疗。药物包括抗抑郁类药物、抗惊厥类药物、阿片类药物及谷氨酸能药物。精心的护理对最大限度缓解患者疼痛,提高其生活质量具有十分重要的作用。
[Abstract]:Central nervous pain (CPSP) is the most common type of central neuropathic pain after stroke, which usually occurs within 6 months after stroke. CPSP.CPSP can occur in any part of the spinal cord thalamus-cortex sensory conduction pathway, and the pathogenesis of CPSP.CPSP is not clear in the younger stroke patients and the vertebrobasilar artery system stroke patients. However, the clinical manifestations of the "central sensitization" and "depress" hypothesis. CPSP are mainly related to the site of the disease, but the main characteristics are pain and abnormal sensation. The pain is burning, squeezing, acupuncture and cold. Or tear like, may be aggravated by emotional tension, cold, heat, fatigue or physical exercise. Although there are many diagnostic criteria for reducing .CPSP after rest, they all lack specificity and need to be combined with medical history, physical examination and imaging data. It is difficult to eliminate pain caused by other causes. CPSP can be treated with drugs, nerve regulation and psychological intervention. Drugs include antidepressants and anticonvulsants. Meticulous nursing care plays an important role in relieving pain and improving the quality of life of patients.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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