血清心肌酶与CSF中LDH、TNF-α检测对成人颅内感染急性期的临床意义

发布时间：2018-02-28 06:16

本文关键词： 乳酸脱氢酶天冬氨酸氨基转移酶类肌酸激酶肿瘤坏死因子-α 颅内感染　出处：《重庆医学》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨检测血清乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)及脑脊液(CSF)中LDH、肿瘤坏因子-α(TNF-α)在成人颅内感染急性期中的价值。方法选取2014年1月至2015年12月该院收治的77例确诊颅内感染患者作为观察组,60例神经系统非感染性疾病患者作为对照组,对比两组患者起病7d内的血清LDH、AST、CK及CSF中LDH、TNF-α水平,并进行亚组分析。结果观察组患者血清中LDH、AST、CK及CSF中LDH、TNF-α水平均明显高于对照组患者,差异有统计学意义(P0.05);化脓性脑膜炎、结核性脑膜炎组患者CSF中LDH水平明显高于病毒性脑炎组(P0.05);化脓性脑膜炎组患者的CSF中TNF-α水平明显高于结核性脑膜炎和病毒性脑膜炎组(P0.05)。结论通过检测血清LDH、AST、CK及CSF中LDH、TNF-α水平有利于辅助诊断颅内感染,同时对于颅内感染的病因具有一定的鉴别价值。
[Abstract]:Objective to investigate the value of serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK) and cerebrospinal fluid (CSF) in detecting LDH- 伪 TNF- 伪 in the acute stage of adult intracranial infection. Seventy-seven patients with intracranial infection were treated in our hospital as the observation group and 60 patients with non-infectious diseases of the nervous system as the control group. The serum LDHASTNF- 伪 levels in the two groups within 7 days after onset were compared, and the subgroup analysis was carried out. Results the serum LDHASTNF- 伪 levels of the patients in the observation group were significantly higher than those in the control group (P 0.05), and there was a significant difference between the two groups (P 0.05), and the subgroup analysis showed that the serum levels of LDHASTNF- 伪 in the patients with suppurative meningitis were significantly higher than those in the control group (P < 0.05). The level of LDH in CSF in tuberculous meningitis group was significantly higher than that in viral encephalitis group, and the level of TNF- 伪 in CSF in suppurative meningitis group was significantly higher than that in tuberculous meningitis group and viral meningitis group P0.05.Conclusion by detecting serum LDHASTX CK and CSF, the level of TNF- 伪 in patients with pyogenic meningitis is higher than that in patients with tuberculous meningitis and viral meningitis. The level of TNF- 伪 in middle LDH is helpful for the diagnosis of intracranial infection. At the same time, the etiology of intracranial infection has certain differential value.
【作者单位】：郑州大学附属南阳分院南阳市中心医院感染性疾病科;郑州大学附属南阳分院南阳市中心医院神经内科;
【分类号】：R742.9

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