PRKAA2基因多态性与恩必普对脑梗死患者疗效的关系

发布时间：2018-03-01 18:19

本文关键词： PRKAA基因基因多态性恩必普脑梗死　出处：《中风与神经疾病杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的研究PRKAA2基因多态性与恩必普对脑梗死患者疗效的关系。方法选取235例脑梗死患者为研究对象,全部服用恩必普胶囊30 d后予NIHSS评分观察恢复情况。应用直接基因测序方法,研究AMPKa2基因7个单倍型标记单核苷酸多态性(tag-SNPs)与脑梗死患者疗效的关系。结果 (1)SNP rs1124900基因型分布频率有显著差异,失效组GG基因型患者分布频率较高,但等位基因频率比较无显著差异,且显效组GG基因型检出率较低。rs17848595位点基因型分布频率有显著差异,失效组AA基因型分布频率较显效组高,但等位基因频率比较无显著差异。rs1418442基因型及等位基因分布频率有显著差异,显效组C等位基因频率显著高于失效组,该位点多态性与恩必普治疗的LAA患者预后有相关获益趋势。结论 AMPK的活化可能是脑缺血缺氧后康复的重要因素。
[Abstract]:Objective to study the polymorphism of PRKAA2 gene and the relationship of dl-3-butylphthalide on patients with cerebral infarction. Methods 235 cases of cerebral infarction patients as the research object, taking all dl-3-butylphthalide capsules after 30 d NIHSS score to observe the recovery situation. Application of direct gene sequencing method, 7 on AMPKa2 gene haplotypes tagging single nucleotide polymorphism (tag-SNPs) and the curative effect in patients with cerebral infarction. Results (1) SNP rs1124900 genotype frequency distribution has significant difference, high failure frequency distribution of patients with GG genotype, but the allele frequency showed no significant difference, and the effective group GG had a lower prevalence of type.Rs17848595 genotype frequencies were significantly different, failure group the distribution of AA genotypes is the effective group high frequency, but the allele frequency of.Rs1418442 had no significant differences between the genotype and allele frequency distribution were significantly different, the effective group C allele frequency The polymorphism of this locus was significantly related to the prognosis of LAA patients. Conclusion activation of AMPK may be an important factor for rehabilitation after cerebral ischemia and anoxia.

【作者单位】：解放军第118医院神经内科;
【基金】：南京军区医学科技创新课题(No.12MA024)
【分类号】：R743.33

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