急性缺血性脑卒中患者1年复发危险因素Cox回归分析

发布时间：2018-03-02 15:41

本文选题：卒中　切入点：动脉硬化　出处：《中华老年心脑血管病杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨与急性缺血性脑卒中患者复发相关的独立危险因素。方法前瞻性收集连续在2012年12月1日~2014年1月31日期间在航天中心医院神经内科住院的395例急性缺血性脑卒中患者资料;2015年1月完成1年随访,首先对患者的人口学资料、动脉粥样硬化危险因素、临床资料、生化指标和影像学资料进行单因素分析,进一步进行多因素Cox回归分析。结果资料不全及失访11例,随访384例,急性缺血性脑卒中患者1年复发率10.9%(复发42例),其中3、6、9个月和1年累积复发率分别为5.7%、9.9%、10.7%、10.9%。单因素Cox回归分析显示,年龄、饮酒、脑梗死、癌症、血红蛋白、空腹血糖、大动脉粥样硬化型脑梗死、小动脉闭塞型脑梗死是急性缺血性脑卒中复发的危险因素。多因素Cox回归分析显示,年龄(RR=1.041,95%CI:1.010~1.073,P=0.008)、空腹血糖(RR=1.079,95%CI:1.022~1.140,P=0.007)、癌症(RR=3.756,95%CI:1.306~10.805,P=0.014)、大动脉粥样硬化型脑梗死(RR=3.066,95%CI:1.490~6.309,P=0.002)是急性缺血性脑卒中复发的独立危险因素。结论年龄、空腹血糖、癌症、大动脉粥样硬化型脑梗死是影响急性缺血性脑卒中患者复发的独立危险因素。
[Abstract]:Objective to investigate the independent risk factors associated with recurrence in patients with acute ischemic stroke. Methods A prospective study was conducted on 395 patients with acute acute deficiency who were hospitalized in the Department of Neurology, Space Center Hospital from December 1st 2012 to January 31st 2014. The data of patients with hemorrhagic stroke were followed up for 1 year on January 2015. The demographic data, risk factors of atherosclerosis, clinical data, biochemical indexes and imaging data were analyzed by univariate analysis and multivariate Cox regression analysis. Results the data were incomplete and missing in 11 cases, and followed up in 384 cases. The one-year recurrence rate of patients with acute ischemic stroke was 10.9% (42 cases of recurrent stroke), in which the cumulative recurrence rates were 5.79.9%, 10.7% and 10.9%, respectively. Univariate Cox regression analysis showed that age, drinking, cerebral infarction, cancer, hemoglobin, fasting blood glucose, hemoglobin, and fasting blood glucose, Atherosclerotic cerebral infarction and arterio-occlusive cerebral infarction were the risk factors for the recurrence of acute ischemic stroke. Multivariate Cox regression analysis showed that, Age RRN 1.04195 CI: 1.010101.073P0.008, FBG 1.079995 CI: 1.022221.140 P0.007, cancer 3.75695CI 1.30610.805P0.0144.Atherosclerotic cerebral infarction RRN 3.06695% CI 1.4909 6.309p 0.002 are independent risk factors for the recurrence of acute ischemic stroke. Conclusion Age, fasting blood glucose, cancer, cancer, cancer, cancer, age, fasting blood glucose, cancer, and cancer are independent risk factors for the recurrence of acute ischemic stroke, and age, fasting blood glucose, cancer, cancer, and cancer are the independent risk factors for the recurrence of acute ischemic stroke. Atherosclerotic cerebral infarction is an independent risk factor for the recurrence of acute ischemic stroke.
【作者单位】：航天中心医院(北京大学航天临床医学院)神经内科;
【基金】：首都卫生发展科研专项资助(2011-6031-04)
【分类号】：R743.3

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