帕金森病患者手指静止性震颤的量化评估

发布时间：2018-03-06 18:16

本文选题：静止性震颤　切入点：帕金森病　出处：《安徽医科大学学报》2017年09期 　论文类型：期刊论文

【摘要】：目的量化评估帕金森病(PD)患者手指静止性震颤程度,以及寻找PD与帕金森综合征(PS)患者鉴别诊断的客观量化指标。方法选取29例PD患者、28例PS患者[其中包括16例多系统萎缩P型(MSA-P)患者和12例血管性帕金森综合征(VP)患者]和39例正常老年人,运用基于传感器技术的手指静止性震颤量化评估系统,采集静止状态下各组受试者的拇指、食指的加速度、角速度,计算拇指、食指的静止性震颤的频率及其震颤波曲线相似熵(ApE n)。结果与正常对照组、MSA-P及VP患者比较,PD患者拇指、食指的静止性震颤的频率增高(P0.05),ApE n数值偏低(P0.05);与正常对照组比较,MSA-P患者拇指、食指的静止性震颤的频率增高(P0.01),拇指ApE n数值偏低(P0.05),食指ApE n差异无统计学意义;与正常对照组比较,VP患者拇指、食指的静止性震颤的频率及ApE n差异无统计学意义。结论拇指、食指的静止性震颤的频率及其ApEn等指标能客观量化评估PD患者手指静止性震颤程度,且可作为PD与PS患者鉴别诊断的客观量化指标。
[Abstract]:Objective to evaluate quantitatively the degree of finger quiescent tremor in patients with Parkinson's disease (PD). Objective quantitative indexes of differential diagnosis between PD and PD patients with PSG were searched. Methods 29 patients with PD and 28 patients with PS [including 16 patients with multisystem atrophy P type MSA-P] and 12 patients with vascular Parkinson's syndrome were selected. And 39 normal elderly people, The finger static tremor quantitative evaluation system based on sensor technology was used to collect the acceleration and angular velocity of thumb, index finger, and calculate the thumb of each group of subjects in static state. The frequency of quiescent tremor of index finger and the similar entropy of tremor wave curve were similar to ApE n.Results the thumb of PD patients was compared with those of MSA-P and VP in normal control group. The frequency of quiescent tremor in index finger was higher than that in normal control group (P 0.05). The frequency of quiescent tremor in index finger was higher than that in control group (P 0.01), and the ApE n of thumb was lower than that of control group (P 0.05). There was no significant difference in ApE n between forefinger and forefinger. There was no significant difference in the frequency of quiescent tremor and ApE n in the thumb and index finger of the patients with VP compared with the control group. The frequency and ApEn of index finger quiescent tremor can be used to evaluate the degree of finger quiescent tremor objectively and can be used as an objective quantitative index for differential diagnosis of PD and PS patients.
【作者单位】：安徽中医药大学;安徽中医药大学神经病学研究所附属医院;广西玉林市中西医结合骨科医院;中国科学院合肥智能机械研究所;
【基金】：安徽高校自然科学研究重大项目(编号:KJ2016SD33) 安徽省科技重大专项项目(编号:16030801122)
【分类号】：R742.5

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