DCE-MRI技术评估脑胶质瘤不成熟微血管密度

发布时间：2018-03-07 03:08

  本文选题：胶质瘤　切入点：动态对比增强　出处：《中国医学计算机成像杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:通过对脑胶质瘤患者进行动态对比增强磁共振成像(DCE-MRI)获得容积转运参数(Ktrans)与血管外细胞外间隙容积比(Ve),探讨DCE-MRI定量评估胶质瘤不成熟微血管密度的价值。方法:研究对象包括66例脑胶质瘤患者,其中Ⅱ级27例,Ⅲ级8例,Ⅳ级31例。每名脑胶质瘤患者术前经过DCE-MRI检查获得胶质瘤的Ktrans与Ve的最大值,术后胶质瘤标本进行免疫组织化学测量CD105阳性标记的微血管密度(CD105-MVD)的最大值。应用Mann-Whitney U检验比较不同级别胶质瘤Ktrans值、Ve值、CD105-MVD的差异,应用Pearman相关系数分析胶质瘤Ktrans值、Ve值与CD105-MVD的相关性。结果:低级别胶质瘤的Ktrans值、Ve值、CD105-MVD均小于高级别胶质瘤(P0.001,P0.001,P0.001)。高级别胶质瘤的Ktrans值、Ve值均与CD105-MVD正相关(P0.001,P0.001)。结论:DCE-MRI可以定量评估脑胶质瘤不成熟微血管密度。
[Abstract]:Objective: to evaluate the value of DCE-MRI in quantitative evaluation of immature microvessel density of gliomas by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and extracellular space volume ratio (ECV) obtained by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Methods: 66 patients with glioma were included in the study. There were 27 cases of grade 鈪，

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