吉兰-巴雷综合征患者脑脊液蛋白水平与周围神经髓鞘损伤的相关性分析

发布时间：2018-03-07 06:00

本文选题：神经免疫　切入点：吉兰　出处：《上海交通大学学报(医学版)》2017年10期 　论文类型：期刊论文

【摘要】：目的·探讨吉兰巴雷综合征(Guillain-Barrésnydrome,GBS)患者脑脊液蛋白水平与周围神经髓鞘损伤的关系及其临床意义。方法·回顾性分析86例GBS患者临床与生化资料,根据周围神经肌电图检测结果将患者分为周围神经髓鞘损伤组与轴索变性组,并比较2组患者间的临床、生化特征;分析脑脊液蛋白水平与周围神经髓鞘损伤的相关性。结果·髓鞘损伤组与轴索变性组之间患者性别、年龄、Hughes残疾量表评分、上呼吸道感染、胃肠感染、皮肤过敏、神经节苷脂钠注射液及免疫球蛋白G(IgG)指数比较,差异无统计学意义(P0.05);周围神经髓鞘损伤组脑脊液蛋白、脑脊液白蛋白/血清白蛋白、IgG与24 h鞘内IgG合成率等指标水平均显著高于周围神经轴索变性组(P0.01);脑脊液蛋白水平与周围神经髓鞘损伤呈正相关(r=0.345,P=0.001)。结论·GBS患者脑脊液蛋白水平越高,周围神经髓鞘损伤发生的可能性越大。脑脊液蛋白水平的分析有助于GBS患者周围神经髓鞘损伤免疫机制的探讨。
[Abstract]:Objective: to investigate the relationship between cerebrospinal fluid protein level and peripheral nerve myelin sheath injury in patients with Guillain-Barr 茅 snydromeg GBS (Guillain-Barr 茅 snydromefen GBS) patients with Guillain-Barr 茅 Guillain-Barr 茅 syndrome of Guillain-Barr 茅. Methods: clinical and biochemical data of 86 patients with GBS were retrospectively analyzed. According to the results of peripheral nerve electromyography, the patients were divided into two groups: peripheral nerve myelin injury group and axonal degeneration group. The clinical and biochemical characteristics of the two groups were compared. The correlation between cerebrospinal fluid protein level and peripheral nerve myelin sheath injury was analyzed. Results: sex, age and age of patients with myelin injury and axonal degeneration, upper respiratory tract infection, gastrointestinal infection, skin hypersensitivity, There was no significant difference in the index of ganglioside sodium injection and immunoglobulin G _ (G) G _ (G), and there was no significant difference between the two groups (P _ (0.05) P _ (0.05)). The levels of cerebrospinal fluid albumin / serum albumin IgG and 24 h intrathecal IgG synthesis were significantly higher than those of peripheral nerve axonal degeneration group P0.01.The cerebrospinal fluid protein level was positively correlated with peripheral nerve myelin sheath injury. Conclusion: conclusion\\\; The higher the level of liquid protein, The analysis of cerebrospinal fluid protein level is helpful to explore the immune mechanism of peripheral nerve myelin sheath injury in patients with GBS.
【作者单位】：南昌大学抚州医学院病原教研室;南昌大学第五附属医院检验科;复旦大学附属华山医院神经内科;
【基金】：上海市卫生和计划生育委员会面上项目(201440347)~~
【分类号】：R745.43

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