苯甲酸利扎曲普坦治疗偏头痛合并卵圆孔未闭的疗效评价

发布时间：2018-03-08 05:23

本文选题：偏头痛　切入点：卵圆孔未闭　出处：《吉林大学》2014年硕士论文　论文类型：学位论文

【摘要】：研究目的：评价苯甲酸利扎曲普坦治疗偏头痛合并卵圆孔未闭的疗效。对象与方法：收集吉林大学白求恩第一医院神经内科2013年5月到2013年12月发泡试验检查阳性偏头痛患者113例为研究对象。随机分为两组，其中服用欧立停者为治疗组，共55例，男15例，女40例，年龄平均36.5±11.14岁；服用抗偏头痛常规用药者为对照组，共58例，男16例，女42例，年龄平均36.2±11.11岁。治疗组服用欧立停5mg，对照组服用抗偏头痛常规药1片，于头痛发作开始时各服。观察患者服药前，服药后0.5ｈ、1ｈ、2ｈ、4ｈ的疼痛缓解、疼痛消失患者比例，，及头痛伴随症状。结果：欧立停5mg较治疗急性期偏头痛的常规药物相比具有更好的疗效。治疗组患者在用药后0.5ｈ、1ｈ、2ｈ、4ｈ的出现头痛缓解分别为30.91%，58.18%，81.81%，94.54%，治疗组服药后4h内出现疼痛缓解的患者比例较对照组高(P0.05)。治疗组患者在用药后0.5ｈ、1ｈ、2ｈ、4ｈ的头痛消失患者比例分别为9.09%，25.45%，53.18%，74.54%，服药后4h内疼痛消失的患者比例较对照组高(P0.05)。经4h治疗后，两组患者均为再出现呕吐症状，恶心、畏光、声也较治疗前明显减低，其中治疗组的恶心症状明显低于对照组（P0.05)。结论：偏头痛患者中卵圆孔未闭的发生率高，而卵圆孔未闭患者中偏头痛发生率高；c-TCD诊断PFO的敏感性及特异性高；目前尚无充分的证据表明行PFO封堵术可以缓解偏头痛发作，是否行封堵仍存在争议；苯甲酸利扎曲普坦治疗合并PFO的偏头痛疗效显著。
[Abstract]:Objective: to evaluate the efficacy of rizatriptan benzoate in the treatment of migraine with patent foramen ovale. Participants and methods: 113 cases of migraine with positive foaming test were collected from May 2013 to December 2013 in Department of Neurology, Bai Qiuen first Hospital, Jilin University. There were 55 cases (15 males, 40 females, mean age 36.5 卤11.14 years), 58 patients (16 males, 42 females) who took routine anti-migraine medication. The average age was 36. 2 卤11. 11 years old. The patients in the treatment group were treated with oletazone 5 mg, the control group took 1 routine antimigraine drug at the beginning of the headache attack. The pain relief, pain disappearance rate and headache associated symptoms were observed at 0.5 h, 1 h and 2 h after the treatment. Results: olipid 5mg was more effective than conventional medicine in treating acute migraine. In the treatment group, the headache relief was 30.91g 58.18g and 81.81R 94.54mg, respectively. In the treatment group, pain relief occurred within 4 hours after taking medicine. The proportion of patients in the treatment group was higher than that in the control group (P 0.05). The proportion of headache disappeared in the treatment group was 9.09 ~ 25.45% and 53.18% respectively. The proportion of the pain disappeared within 4 hours after taking the drug was higher than that in the control group (P 0.05). After 4 hours of treatment, the proportion of the patients in the treatment group was higher than that in the control group (P 0.05). The symptoms of vomiting, nausea, photophobia and noise in both groups were significantly lower than those before treatment, and the nausea symptoms in the treatment group were significantly lower than those in the control group (P 0.05). Conclusion: the incidence of patent foramen ovale in patients with migraine is high, while the incidence of migraine in patients with patent foramen ovale is high. Whether or not to block is still controversial, and rizatriptan benzoate is effective in the treatment of migraine with PFO.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R747.2

【参考文献】