丁苯酞对卒中后抑郁的疗效观察及作用机制研究

发布时间：2018-03-09 22:10

本文选题：卒中后抑郁　切入点：丁苯酞　出处：《中国现代医生》2016年36期 　论文类型：期刊论文

【摘要】：目的探讨丁苯酞用于卒中后抑郁(post-stroke depression,PSD)治疗的有效性、可行性。方法以2015年3月~2016年2月我院收治的171例PSD患者为研究对象,本次临床分组采用双盲法将患者分为常规、观察、治疗三组,每组57例。其中常规组采用艾司西酞普兰治疗,观察组以丁苯酞治疗,治疗组以两种药物联合治疗,对用药前后患者抑郁、脑卒中恢复情况进行评估,并比较NIHSS、HAMD、m RS评分。检查用药前后患者超敏C反应蛋白(hypersensitive C-reactive protein hs-CRP)、去甲肾上腺素(Noradrenaline,NE)情况,统计治疗期间用药所致不良反应。结果治疗前患者美国国立卫生研究所脑卒中量表(National Institute of Health stroke scale,NIHSS)评分、汉密顿抑郁量表(Hamilton Depression Scale,HAMD)、改良Rankin量表(Modified Rankin Scale,m RS)评分比较差异无统计学意义(P0.05),用药后各组患者NIHSS、HAMD、m RS评分均有改善,治疗组、观察组评分低于常规组,且治疗组患者卒中、抑郁恢复情况优于观察组(P0.05);治疗前患者NE、hs-CRP差异无统计学意义(P0.05),服药后治疗组指标恢复优于常规组、观察组,且治疗组恢复情况较观察组好(P0.05)。结论临床对卒中后抑郁患者使用艾司西酞普兰、丁苯酞联合治疗效果好。
[Abstract]:Objective to investigate the efficacy and feasibility of butyphthalide in the treatment of post-stroke depression (PSD). Methods from March 2015 to February 2016, 171 patients with PSD were treated in our hospital. There were 57 cases in each of the three groups. The routine group was treated with estalopram, the observation group was treated with butadiphthalide, and the treatment group was treated with two kinds of drugs. The depression and the recovery of stroke were evaluated before and after the treatment. The HMDM RS score of NIHSS was compared. The hypersensitive C-reactive protein hs-CRP (noradrenaline nebula) was detected before and after the treatment. Results before treatment, the National Institute of Health stroke scale and NIHSS scores were measured. There was no significant difference between Hamilton Depression scale and modified Rankin scale in the scores of Hamd and modified Rankin scale. After treatment, the scores of NIHSS and HAMDM RS in all groups were improved. In the treatment group, the scores in the observation group were lower than those in the routine group, and the stroke of the patients in the treatment group was lower than that in the control group. The recovery of depression was better than that of observation group (P 0.05), the difference of NEH-CRP before treatment was not significant (P 0. 05%), the index of treatment group was better than that of routine group (P 0. 05%). The recovery of the treatment group was better than that of the observation group P0.05.Conclusion the clinical effect of Escitalopram combined with butyrophthalide in patients with post-stroke depression is better than that in the control group.
【作者单位】：温州医科大学附属乐清医院神经内科;
【基金】：浙江省温州市医药卫生科研项目(2014A15)
【分类号】：R743.3;R749.4

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