依达拉奉在预防控制脑梗死患者感染发生及免疫调节中的作用

发布时间：2018-03-10 01:35

本文选题：依达拉奉　切入点：脑梗死　出处：《中华医院感染学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨依达拉奉在预防和控制脑梗死患者感染发生及免疫调节中的作用效果,为临床用药提供依据。方法选取2014年12月-2015年12月医院收治的脑梗死患者130例,根据患者临床治疗方法的不同分为研究组和对照组,每组65例;对照组患者给予常规治疗,研究组在对照组的基础上加用依达拉奉进行治疗;对患者的感染发生情况、红细胞C3b受体花环率、红细胞免疫复合物花环率和红细胞免疫黏附促进因子等红细胞免疫功能指标和全血粘度、血浆粘度、血细胞比容、红细胞聚集指数等血液流变学指标进行观察和比较,同时对导致感染发生的危险因素进行分析。结果治疗1周和2周后,研究组患者的各项红细胞免疫功能指标和血液流变学指标均明显优于对照组,且差异有统计学意义(P0.05);研究组感染率为10.77%,低于对照组的41.54%,且差异有统计学意义(P0.05);年龄、NIHHS评分、意识障碍和住院时间是脑梗死患者感染的独立危险因素。结论脑梗死患者的感染情况严重,年龄、NIHHS评分、意识障碍和住院时间是脑梗死患者感染的独立危险因素,依达拉奉在预防脑梗死患者感染以及调节患者免疫机制的过程中效果明显。
[Abstract]:Objective to investigate the effect of edaravone on the prevention and control of infection occurrence and immune regulation in patients with cerebral infarction, and provide the basis for clinical treatment. Methods 130 patients with cerebral infarction in December 2014 -2015 year in December admitted to the hospital, according to different clinical treatment methods into study group and control group, 65 cases in each group; the control group were given routine treatment the research group, on the basis of the control group was treated with edaravone; the occurrence of infection, erythrocyte C3b receptor rosette rate of red cell immune complex rosette rate and RBC immune adherence promoting red blood cell immune factor function and blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index hemorheological indexes were observed and compared, and the risk factors for infection were analyzed. Results after 1 weeks and 2 weeks, the study group patients The red blood cell immune function index and hemorheology index were significantly better than the control group, and the difference was statistically significant (P0.05); the study group infection rate was 10.77%, lower than 41.54% in the control group, and the difference was statistically significant (P0.05); age, NIHHS score, disturbance of consciousness and hospitalization time were independent risk factors of cerebral infarction infection of patients with infection. Conclusion patients with cerebral infarction severity, age, NIHHS score, disturbance of consciousness and hospitalization time were independent risk factors of infection in patients with cerebral infarction, edaravone in the prevention of infection in patients with cerebral infarction and the effect process of regulating immune system in patients with obvious.

【作者单位】：绍兴第二医院神经内科;
【分类号】：R743.33

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