帕金森病睡眠障碍特点及分析

发布时间：2018-03-10 02:34

本文选题：帕金森病　切入点：睡眠障碍　出处：《新疆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：使用一整夜PSG(多导睡眠图)客观地分析PD(帕金森病)患者睡眠障碍及特点,探索PD睡眠障碍潜在的影响因素及可能的发生机制。方法：对33名PD患者和年龄、体重指数等相匹配的33名健康对照者行一整夜多导睡眠图监测并对记录数据进行分析。结果：PD组与对照组早醒(4例(12.1%)vs0例(0%))、睡眠破碎(25例(75.8%)vs16例(48.5))、快动眼睡眠期颏肌失张力消失(16例(48.5%) vs3例(9.1%)),PD组的检出率均显著高于对照组(P0.05)；PD组和对照组睡眠结构参数比较,两组在S2%、S4%上没有显著差别；PD组觉醒时间占总睡眠时间%、NREM%、S1%显著多于对照组,而S3%和REM%显著少于对照组；PD病程≤2年组和对照组比较,两者睡眠结构参数均无统计学差异；PD病程2年组和对照组比较,PD组觉醒时间占总睡眠时间%、NREM%、S1%显著多于对照组,S3%、S4%及REM%明显少于对照组；PD病程≤2年组和PD病程2年组比较,后者在觉醒时间占总睡眠时间%明显多于前者,而REM%明显少于前者。结论：1、帕金森病患者睡眠障碍主要表现为早醒、睡眠破碎和快动眼睡眠期赅肌失张力消失；2、帕金森病患者明显存在睡眠结构,浅睡期时间延长,深睡期时间缩短,这主要是疾病本身及病程、年龄、药物等共同作用的结果；3、PD病程对其睡眠影响较大,但即使在帕金森病早期,仍然存在着睡眠机制的损害。
[Abstract]:Objective: to objectively analyze sleep disorders and characteristics of patients with PD (Parkinson's disease) by using PSG overnight. Methods: 33 patients with PD and their age were studied in order to explore the possible influencing factors and possible pathogenesis of PD sleep disorders. Thirty-three healthy controls matched body mass index were monitored by overnight polysomnography and the recorded data were analyzed. Results four cases of early waking up in the control group and the control group were found to wake up earlier than 12.1vs0 cases, 25 cases with sleep breakage and 25 cases with sleep breakage, with 75.8% vs 16 cases with 48.5%, and with rapid eye movement sleep phase with chin muscle. The detectable rate of PD in vs3 group was significantly higher than that in control group (P 0.05) and control group (P < 0.05), and the sleep structure parameters of PD group were significantly higher than those of control group (P < 0.05), and the sleep structure parameters of PD group were significantly higher than those of control group (P < 0.05). There was no significant difference in S2 / S4% between the two groups. The awakening time in PD group was significantly higher than that in the control group (1%), while S3% and REM% were significantly lower than those in the control group (P < 2). There was no significant difference in sleep structure parameters between the two groups. The awakening time of PD group was significantly higher than that of control group (P < 2). The ratio of waking time to total sleep time in PD group was significantly higher than that of control group (P < 0. 01%, P < 0. 01%, P < 0. 01%, P < 0. 01%, P < 0. 05). The percentage of total sleep time in the latter group was significantly higher than that in the former, while the REM% was significantly lower than that in the former. Conclusion: 1, sleep disorders in Parkinson's disease patients are mainly characterized by early waking up. In patients with Parkinson's disease, sleep structure is obvious, the duration of shallow sleep is prolonged, and the time of deep sleep is shortened. This is mainly the disease itself and the course of disease, age, etc. The results of the combined effects of drugs and other drugs on the duration of PD have a great influence on sleep, but even in the early stage of Parkinson's disease, sleep mechanism is still impaired.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5

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