rt-PA静脉溶栓治疗不同时间窗椎-基底动脉系统脑梗死的临床疗效观察

发布时间：2018-03-10 10:04

本文选题：重组组织型纤溶酶原激活剂　切入点：椎-基底动脉系统　出处：《中风与神经疾病杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨椎-基底动脉系统脑梗死患者不同时间窗重组组织型纤溶酶原激活剂(recombinant tissue plasminogen activator,rt-PA)静脉溶栓治疗的临床疗效。方法回顾性分析50例椎-基底动脉系统脑梗死患者临床资料,按溶栓治疗时间窗分为4.5 h组和4.5~9 h组,每组25例。比较两组患者神经功能缺损量表(national institutes of health stroke scale,NIHSS)评分、Barthel指数(Barthel index,BI)评分、改良Rankin量表(modified Rankin scale,mRS)评分及脑出血发生率。结果与治疗前相比较,治疗后14 d、30 d、90 d时4.5 h组和4.5~9 h组NIHSS评分和BI评分均显著升高,组间比较差异显著(P0.05)。治疗前及治疗后14 d、30 d、90 d,两组患者NIHSS评分和BI评分比较均无统计学差异(P0.05)。治疗后90 d,两组患者mRS评分比较无统计学差异(P0.05)。4.5 h组和4.5~9 h组BI评分脑出血发生率分别为4.0%(1/25)、8.0%(2/25),组间比较差异无统计学意义。结论椎-基底动脉系统脑梗死患者发病9 h内应用rt-PA静脉溶栓治疗是安全有效的。
[Abstract]:Objective to investigate the vertebrobasilar artery system in patients with cerebral infarction in different time windows of recombinant tissue type plasminogen activator (recombinant tissue plasminogen activator, rt-PA) the clinical curative effect of intravenous thrombolytic therapy. Methods Retrospective analysis of 50 cases of vertebrobasilar cerebral infarction in patients with clinical data, according to the time window of thrombolytic therapy were divided into 4.5 groups h and 4.5~9 H group, 25 cases in each group. Comparison of two groups of patients with neurological deficit scale (National Institutes of Health Stroke Scale, NIHSS Barthel index (Barthel) score, index score, BI), modified Rankin scale (modified Rankin scale, mRS) score and incidence of cerebral hemorrhage. Results compared with before treatment, after treatment 14 d, 30 d, 90 d 4.5 h group and 4.5~9 H group NIHSS score and BI score were significantly increased, significant difference between the two groups (P0.05). Before and after treatment for 14 d, 30 d, 90 d, two groups of patients with NIHSS score and BI score There was no statistical difference (P0.05). 90 d after treatment, no significant differences between the two groups of patients with mRS score (P0.05) was respectively 4%.4.5 H group and 4.5~9 score of cerebral hemorrhage group H BI (1/25), 8% (2/25), no statistically significant difference between groups. Conclusion the treatment of vertebral disease the application of rt-PA in patients with cerebral infarction within 9 h intravenous thrombolysis in basilar artery system is safe and effective.

【作者单位】：南阳市中心医院神经内科;
【分类号】：R743.3

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