颅内动脉瘤患者肿瘤坏死因子-α和白细胞介素-6的表达及其作用机制

发布时间：2018-03-11 18:27

本文选题：颅内动脉瘤　切入点：肿瘤坏死因子-α　出处：《中国老年学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨颅内动脉瘤患者肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6的表达及其作用机制。方法该院收治的颅内动脉瘤患者60例为研究组,另选取同期健康体检者60例为对照组,研究组给予脑动脉瘤介入栓塞术治疗,检测研究组治疗前后和对照组血清中TNF-α和IL-6水平,研究组根据血管壁厚度分为增厚组(36例)和非增厚组(24例),比较各组TNF-α和IL-6水平,并分析TNF-α和IL-6的相关性。结果研究组治疗前TNF-α和IL-6水平显著高于治疗后和对照组(P0.05),治疗后两组比较无统计学差异(P0.05);增厚组TNF-α和IL-6水平显著高于非增厚组(P0.05);Spearman相关性分析显示,TNF-α与IL-6呈正相关(P0.05)。结论颅内动脉瘤患者血清中TNF-α与IL-6表达水平升高可能与颅内动脉瘤生成和破裂有关。
[Abstract]:Objective to investigate the expression and mechanism of tumor necrosis factor TNF- 伪 and interleukin-6 in patients with intracranial aneurysms. Methods 60 patients with intracranial aneurysms treated in our hospital were selected as study group and 60 healthy persons as control group. The study group was treated with interventional embolization of cerebral aneurysms. The levels of TNF- 伪 and IL-6 were measured before and after treatment in the study group and in the control group. The patients in the study group were divided into thickening group (36 cases) and non-thickened group (24 cases) according to the thickness of vascular wall. The levels of TNF- 伪 and IL-6 in each group were compared. Results the levels of TNF- 伪 and IL-6 in the study group before treatment were significantly higher than those in the control group (P 0.05), but there was no significant difference between the two groups after treatment (P 0.05), and the levels of TNF- 伪 and IL-6 in the thickening group were significantly higher than those in the non-thickening group (P 0.05). Conclusion the increased expression of TNF- 伪 and IL-6 in the serum of patients with intracranial aneurysms may be related to the formation and rupture of intracranial aneurysms.
【作者单位】：郑州大学附属南阳医院南阳市中心医院神经内科;
【分类号】：R743

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