肝豆灵片联合二巯丙磺酸钠对痰瘀互结型肝豆状核变性患者血清丙二醇、超氧化物歧化酶的影响

发布时间：2018-03-12 12:02

本文选题：肝豆灵片　切入点：二巯丙磺酸钠　出处：《中国实验方剂学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的:观察肝豆灵联合二巯丙磺酸钠治疗对痰瘀互结型肝豆状核变性患者血清丙二醇(MDA),超氧化物歧化酶(SOD)的影响,并探讨其作用机制。方法:选取安徽中医药大学第一附属医院脑病科确诊为肝豆状核变性的住院患者120例,随机分为对照组和治疗组,各60例,其中对照组使用二巯丙磺酸钠常规治疗,治疗组在常规治疗的基础上加用肝豆灵片,治疗4个疗程。在治疗前后分别进行血清MDA,SOD,24 h尿铜、神经功能评分等相关指标评估。结果:与治疗前比较,两组治疗后血清MDA含量均减低,SOD活性均增加(P0.05),治疗组优于对照组(P0.01);两组神经功能评分均下降(P0.05),治疗组疗效优于对照组(P0.01);两组治疗后24 h尿铜均有明显改善,其中治疗组改变显著(P0.01),治疗组驱铜效果优于对照组(P0.05);两组肝功能指标均有降低(P0.05),治疗组显著优于对照组(P0.01)。两组铜蓝蛋白与铜氧化酶治疗前后变化不大。根据两组不良反应分析,发现治疗组副作用小。结论:中西医结合治疗能明显降低肝豆状核变性患者中血清MDA含量,增加SOD活性,可以加强驱铜效果,改善临床症状,在一定程度上可以延缓病情进展,减轻患者痛苦。且不良反应较少,安全性高,在临床上得到广泛运用。
[Abstract]:Objective: to observe the effect of Gantouling combined with sodium dimercaptopropanesulfonate on serum propanediol MDAA, superoxide dismutase (SOD) in patients with phlegm-blood stasis syndrome of hepatolenticular degeneration. Methods: 120 inpatients diagnosed as hepatolenticular degeneration in Department of Encephalopathy, the first affiliated Hospital of Anhui University of traditional Chinese Medicine, were randomly divided into control group and treatment group with 60 cases each. The control group was treated with sodium dimercaptopropanesulfonate, the treatment group was treated with Gantouling tablet on the basis of routine treatment, and the serum MDA-SOD was used for 24 h urine copper before and after treatment. Neurological function score and other related indicators. Results: compared with before treatment, After treatment, the content of MDA in serum of both groups decreased and the activity of sod increased. The treatment group was superior to the control group in P0.01, the scores of nerve function in both groups were decreased, the curative effect was better than that in the control group, and the urine copper in both groups was obviously improved 24 hours after treatment. The effect of copper displacing in the treatment group was better than that in the control group (P 0.05), the liver function index in both groups was lower than that in the control group, and the treatment group was significantly better than that in the control group (P 0.01). The changes of copper blue protein and copper oxidase in the two groups were not significant before and after treatment, according to the analysis of adverse reactions between the two groups, there was no significant difference between the two groups before and after treatment. Conclusion: the combination of traditional Chinese and western medicine can obviously reduce the content of serum MDA and increase the activity of SOD in the patients with hepatolenticular degeneration. It can strengthen the effect of copper displacing, improve the clinical symptoms, and delay the progress of the disease to a certain extent. Ease the pain of patients, and less adverse reactions, high safety, has been widely used in clinical.
【作者单位】：安徽中医药大学第一附属医院;安徽中医药大学研究生部;
【基金】：国家自然科学基金项目(81102592) 安徽省高校省级自然科学研究项目(KJ2013Z170)
【分类号】：R742.4

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