老年患者头颅MR腔隙灶改变与尿微量白蛋白的相关关系及其危险因素的探讨

发布时间：2018-03-13 16:44

本文选题：腔隙灶　切入点：尿微量白蛋白　出处：《实用医学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨70岁以上患者头颅MR腔隙灶改变与尿微量白蛋白(MAU)间的相关关系及MR腔隙灶改变的危险因素。方法:本组资料中的研究对象均来自2014年1-12月于广州市第一人民医院老年病科住院的70岁以上的老年患者。记录其年龄、性别、吸烟史、饮酒史、收缩压、高血压史、糖尿病史、冠心病史、非瓣膜性心房颤动病史,以及尿素氮、肌酐、尿酸、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、超敏C-反应蛋白、MAU、头颅MR等结果。根据头颅MR改变,分为无腔隙灶组和有腔隙灶组。结果:(1)与无腔隙灶患者比较,有腔隙灶组患者动脉收缩压较高,同时MAU阳性率升高、MAU中位数也明显升高。(2)多因素Logistic回归分析提示,动脉收缩压升高、MAU阳性以及MAU升高均为是否发生腔隙灶改变的独立危险因素,并且均与腔隙灶的严重程度呈正相关。结论:MAU是头颅MR腔隙灶改变的危险因素。年龄、高血压是头颅MRI腔隙灶改变的危险因素。
[Abstract]:Objective: to investigate the correlation between the changes of cranial Mr lacunae and urinary albumin in patients over 70 years old and the risk factors for the changes of Mr lacunae. Methods: all the subjects in this study were from 2014 to December in Guangzhou. Elderly patients over 70 years of age hospitalized in the Geriatrics Department of the first people's Hospital. Gender, history of smoking, history of alcohol consumption, systolic blood pressure, history of hypertension, history of diabetes, history of coronary heart disease, history of non-valvular atrial fibrillation, and urea nitrogen, creatinine, uric acid, total cholesterol, triglyceride, high density lipoprotein cholesterol, Low density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive protein (HDP-MAU), cranial Mr, etc. According to the changes of cranial Mr, they were divided into two groups: no lacunar focus group and lacunar focus group. Results compared with the patients with lacunar focus, the systolic blood pressure of artery was higher in the patients with lacunar foci. Multivariate Logistic regression analysis showed that elevated arterial systolic blood pressure and increased MAU were independent risk factors for the change of lacunar foci. Conclusion:% mau is a risk factor for the change of cranial Mr lacunae, and age, hypertension is the risk factor for the change of cranial MRI lacunar foci.
【作者单位】：广州市第一人民医院老年病科;广州医科大学附属第二医院神经内科;
【基金】：广州市医药卫生科技项目(编号:20151A010012)
【分类号】：R445.2;R743

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