盐酸普拉克索添加治疗帕金森病的临床疗效及对视觉诱发电位P100潜伏期的影响

发布时间：2018-03-14 10:25

本文选题：帕金森病　切入点：盐酸普拉克索　出处：《国际神经病学神经外科学杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨盐酸普拉克索联合多巴丝肼片治疗帕金森病(PD)的临床疗效及对视觉诱发电位P100潜伏期的影响。方法选择2014年3月至2016年4月收治的PD患者60例为研究对象,将60例患者分为对照组(28例)和观察组(32例)。对照组予以多巴丝肼片治疗,观察组在多巴丝肼片基础上联合盐酸普拉克索,共治疗12周。两组患者治疗前及治疗后均采用PD评分量表第III部分(UPDRS III)进行评分,比较治疗疗效。两组患者在治疗前及治疗12周后行视觉诱发电位检查,观察P100潜伏期情况。结果观察组治疗的显效率(71.88%)和总有效率(90.63%)明显高于对照组(39.29%和64.29%),差异有统计学意义(P0.05,P0.01)。治疗12周后UPDRS评分,观察组(24.21±12.12)明显低于对照组(16.14±10.12),差异有统计学意义(P0.05)。两组患者治疗前P100潜伏期均明显延长,两组之间无显著差异(P0.05)。治疗12周后,观察组P100潜伏期较治疗前显著缩短(P0.05);对照组P100潜伏期较治疗前无变化(P0.05)。结论盐酸普拉克索联合多巴丝肼片治疗帕金森病,可显著改善患者运动症状,且可以显著缩短P100潜伏期。
[Abstract]:Objective to investigate the clinical efficacy of praxol hydrochloride combined with dobutazid tablets in the treatment of Parkinson's disease (PD) and its effect on P100 latency of visual evoked potential (VEP). Methods from March 2014 to April 2016, 60 patients with PD were selected as subjects. 60 patients were divided into control group (n = 28) and observation group (n = 32). After 12 weeks of treatment, the patients in both groups were evaluated with PD score scale (part III) before and after treatment, and the therapeutic effects were compared. Visual evoked potentials (VEP) were examined before and after 12 weeks of treatment in the two groups. Results the effective rate (71.88) and the total effective rate (90.63) in the observation group were significantly higher than those in the control group (39.29% and 64.29%, respectively). The difference was statistically significant (P 0.05 P 0.01). After 12 weeks of treatment, the UPDRS score was significantly higher than that in the control group. The latency of P100 in the observation group (24.21 卤12.12) was significantly lower than that in the control group (16.14 卤10.12), and the difference was statistically significant (P 0.05). The latency of P100 in the two groups was significantly prolonged before treatment, and there was no significant difference between the two groups after 12 weeks of treatment. The latency of P100 in the observation group was significantly shorter than that before treatment, while that in the control group was not changed compared with that before treatment. Conclusion the treatment of Parkinson's disease with praxol hydrochloride combined with dobutazid tablets can significantly improve the motor symptoms and shorten the latency of P100.
【作者单位】：南京医科大学第二附属医院神经内科;
【分类号】：R742.5

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