碳离子辐照对神经胶质瘤干细胞杀伤的研究

发布时间：2018-03-15 07:36

本文选题：重离子　切入点：辐照　出处：《原子核物理评论》2017年02期 　论文类型：期刊论文

【摘要】：虽然重离子束治癌已经被证明有着射程精确、入口坪区剂量小、相对生物学效应高等显著优点,但重离子辐照对肿瘤干细胞所产生的辐射生物学效应特性依旧不明确。本研究使用人源神经胶质瘤干细胞来研究在面对肿瘤干细胞时,重离子相对于传统X射线是否有明显的生物学优势。实验结果证明,在神经胶质瘤干细胞中,2 Gy碳离子造成的DNA损伤的修复率比X射线造成的损伤修复率要低;MTT实验则证明经过碳离子辐照的肿瘤干细胞活力要比X射线辐照的肿瘤干细胞低得多。综上所述,面对神经胶质瘤干细胞,碳离子能更有效地靶向肿瘤干细胞从而相对于传统X射线有明显的生物学优势。这些发现对于更好地理解重离子束治癌相关的生物学效应有重要的作用。
[Abstract]:Although the treatment of cancer by heavy ion beam has been proved to have a precise range, a small dose at the entrance plateau, and a significant advantage over the biological effect, However, the radiobiological effects of heavy ion irradiation on tumor stem cells are still unclear. In this study, human glioma stem cells were used to study tumor stem cells. Whether heavy ions have obvious biological advantages over conventional X-ray. The repair rate of DNA damage caused by 2 Gy carbon ion in glioma stem cells is lower than that caused by X-ray. Stem cells are much lower. To sum up, In the face of glioma stem cells, Carbon ions can target tumor stem cells more effectively and thus have obvious biological advantages over conventional X-ray. These findings play an important role in better understanding the biological effects of heavy ion beam therapy on cancer.
【作者单位】：中国科学院近代物理研究所空间辐射生物学实验室;中国科学院大学;中国科学院昆明动物研究所动物模型与人类疾病机理重点实验室;
【基金】：国家自然科学基金资助项目(31270895,U1232125,31400723,11335011)~~
【分类号】：R739.4

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