载脂蛋白E基因多态性与心脑血管疾病的相关性

发布时间：2018-03-16 01:31

本文选题：载脂蛋白E　切入点：心脑血管疾病　出处：《实用医学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨载脂蛋白E(Apo E)基因多态性在常见心脑血管的发生发展中所起的作用。方法应用基因芯片方法检测1 427例心脑血管疾病患者和450例健康体检者的Apo E基因型,并比较Apo E不同表型患者血脂水平。结果病例组和对照组Apo E基因型均以ε3/3频率最高;ApoE等位基因频率从高到低依次为ε3、ε2和ε4;其中病例组ε3/3基因型低于对照组(χ~2=12.562,P0.01),而ε3/4基因型高于对照组(χ~2=27.442,P0.01),病例组ε3等位基因频率低于对照组(χ~2=12.406,P0.01),而ε4基因频率高于对照组(χ~2=36.112,P0.01);病例组各组间的ApoE基因型和等位基因频率之间差异无统计学意义(P0.05)。病例组TCH、TG、LDL-c和sd LDL均显著高于对照组,HDL-c显著降低,差异具有统计学意义(P0.05);E2型患者TCH及LDL-c水平显著降低(P0.05),而E4型患者TCH及LDL-c水平显著升高(P0.05),其余指标未发现显著差异(P0.05);ApoE基因型及ApoE表型均与LDL-c水平呈正相关(P0.01)。结论 ApoE基因多态性在心脑血管疾病的发生发展中起着重要的作用。
[Abstract]:Objective to investigate the role of apolipoprotein E (apo) gene polymorphism in the occurrence and development of common cardiovascular and cerebrovascular diseases. Methods the Apo E genotypes of 1 427 patients with cardiovascular and cerebrovascular diseases and 450 healthy controls were detected by gene chip method. Results the highest frequency of 蔚 3/3 allele was 蔚 3, 蔚 2 and 蔚 4 in the patients with different phenotypes of ApoE, and the 蔚 3/3 genotype was lower in the case group than in the control group (蠂 2, 12.562, P 0.01, P 0.01), and the frequency of 蔚 3/3 was lower in the case group than that in the control group (P < 0.05), and the frequency of 蔚 3/3 allele was lower in the case group than in the control group (P < 0.05). The frequency of 蔚 3 allele was lower in the case group than that in the control group (蠂 ~ 2 / 26.442) and 蔚 _ 4 gene frequency was higher than that in the control group (蠂 ~ (2)) (蠂 ~ (2) ~ (2)) 36.112 / P ~ (0.01). There was no significant difference in the ApoE genotype and allele frequency between the two groups (P0.05A, P < 0.05), but the frequency of 蔚 _ (4) allele was higher than that of the control group (蠂 ~ (2 +)) (P < 0.05). Both LDL-c and SD LDL of TCHG were significantly lower than those of control group. The levels of TCH and LDL-c in P0.05 / E2 patients were significantly decreased, while the levels of TCH and LDL-c in E4 patients were significantly increased (P 0.05). There was no significant difference in other indexes. There was a positive correlation between LDL-c level and the genotype of ApoE and the phenotype of ApoE. ApoE gene polymorphism plays an important role in the occurrence and development of cardiovascular and cerebrovascular diseases.
【作者单位】：广东省佛山市第一人民医院检验科;
【分类号】：R54;R743

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