丁苯酞软胶囊改善老年缺血性脑卒中中远期预后的疗效

发布时间：2018-03-17 00:36

本文选题：丁苯酞　切入点：缺血性脑卒中　出处：《中国老年学杂志》2017年24期 　论文类型：期刊论文

【摘要】：目的评价丁苯酞软胶囊对老年缺血性脑卒中中远期预后的安全性及有效性。方法采用前瞻性研究方法,连续收集急性缺血性脑卒中老年患者68例,治疗组35例,对照组33例,在标准化缺血性脑卒中二级预防方案治疗基础上,治疗组加用丁苯酞软胶囊,0.2 g口服,每日3次,共6个月。经颅多普勒(TCD)检测脑侧支循环改善情况,美国国立卫生研究院脑卒中量表(NIHSS)评价神经功能缺损,Barthel指数(BI)评价生活能力改变。观察治疗6个月后脑卒中复发率、病死率、不良反应(恶心、肝肾功能损害、出血等)发生率、脑侧支循环改善情况、神经功能缺损及生活能力改变情况。结果两组年龄、性别、既往史、吸烟饮酒史无显著差异。两组治疗前NIHSS评分(P=0.30)、BI评分(P=0.76)及责任血管血流速度(P=0.63)比较均无显著差异。治疗组患者6个月脑卒中复发率较对照组明显降低(0%vs 18.2%,P=0.03),侧支循环改善优于对照组(37.1%vs 12.1%,P=0.02);两组治疗后的NIHSS评分均较治疗前明显减少(P0.05),BI得分明显增加(P0.05);与对照组相比,治疗组6个月NIHSS评分减少,BI得分增加更明显(均P0.05)。治疗组1例出现轻度恶心,但未影响治疗;两组均未见死亡及过敏反应和肝肾功能损害、出血等严重不良反应。结论丁苯酞软胶囊改善老年缺血性脑卒中中远期预后安全有效。
[Abstract]:Objective to evaluate the safety and efficacy of butyphthalide soft capsule in the middle and long term prognosis of senile ischemic stroke. Methods 68 elderly patients with acute ischemic stroke, 35 patients in treatment group and 33 patients in control group were collected by prospective study. On the basis of standardized secondary prophylaxis regimen for ischemic stroke, the treatment group was treated with butyphthalide soft capsule 0.2 g orally, 3 times a day for 6 months. The improvement of collateral circulation was detected by transcranial Doppler imaging (TCD). The National Institutes of Health Stroke scale (NIHSS) was used to evaluate the changes of living ability by Barthel Index (BI). The recurrence rate, mortality, adverse reactions (nausea, liver and kidney dysfunction) of stroke after 6 months of treatment were observed. The incidence of hemorrhage, the improvement of cerebral collateral circulation, the neurological deficit and the change of living ability. There was no significant difference in the history of smoking and drinking between the two groups before treatment. There was no significant difference between the two groups in NIHSS score 0.30 and BI score 0.76) and the blood flow velocity of responsible vessels was 0.63). The recurrence rate of stroke in the treatment group was significantly lower than that in the control group at 6 months compared with that in the control group, and the collateral circulation was significantly lower in the treatment group than in the control group. The improvement was better than that in the control group (37. 1 vs 12. 01). The NIHSS score after treatment in both groups was significantly lower than that before treatment, and the BI score of P0. 05 was significantly increased compared with that in the control group. In the treatment group, the decrease of NIHSS score at 6 months and the increase of BI score were more obvious (all P 0.05). One case in the treatment group developed mild nausea, but did not affect the treatment, no death, allergic reaction and liver and kidney function damage were found in both groups. Conclusion Buphthalide soft capsule can improve the middle and long term prognosis of senile ischemic stroke.
【作者单位】：暨南大学附属珠海医院神经内科;
【基金】：珠海市科技计划项目(2014D0401990022)
【分类号】：R743.3

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