长时血压变异性与脑白质病变的相关性研究

发布时间：2018-03-17 02:34

本文选题：血压变异性　切入点：脑白质病变　出处：《中风与神经疾病杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨长时血压变异性(blood pressure variability,BPV)与脑白质病变(white matter lesions,WML)发病及严重程度的关系。方法选取符合条件的136例住院患者作为研究对象,每(20±10)d随诊间测量血压,随访12 m,采用改良Scheltens量表评定WML严重程度;分析两组患者的长时血压变异性指标(平均收缩压、平均舒张压、收缩压变异系数、舒张压变异系数、收缩压标准差、舒张压标准差等)。结果 (1)WML组患者平均收缩压、平均舒张压、收缩压变异系数、舒张压变异系数、收缩压标准差、舒张压标准差分别为(135.71±19.84)mmHg、(79.22±15.36)mm Hg、9.08±2.10、11.86±1.49、13.81±3.52、10.12±2.53,高于对照组的(124.88±17.96)mm Hg、(74.33±7.68)mm Hg、7.06±1.85、10.47±1.29、11.17±2.13、9.80±2.45,差异均有统计学意义(P0.05);(2)WML组改良Scheltens量表评分,不同程度患者之间比较,收缩压水平、收缩压变异系数、收缩压标准差差异有统计学意义(P0.05)。结论年龄、高血压、BPV增大是WML的危险因素,长时BPV对WML的发生及进展有一定的预测作用。
[Abstract]:Objective to investigate the relationship between long term blood pressure variability (pressure) and the incidence and severity of white matter lesions (WMLs). Methods 136 inpatients who were in accordance with the criteria were selected to measure their blood pressure at follow-up intervals of 20 卤10 days. The severity of WML was evaluated by modified Scheltens scale, and the indexes of long-term blood pressure variability (mean systolic blood pressure, mean diastolic blood pressure, systolic blood pressure variation coefficient, diastolic blood pressure variation coefficient, systolic blood pressure standard deviation) were analyzed. Results the mean systolic blood pressure, mean diastolic blood pressure, systolic blood pressure variation coefficient, diastolic blood pressure variation coefficient, systolic blood pressure standard deviation, and so on. The standard deviation of diastolic blood pressure was 79.22 卤15.36mm Hgn 9.08 卤2.10mm. 11.86 卤1.4913.81 卤3.52n 10.12 卤2.53, respectively, which was higher than that of control group (124.88 卤17.96mm), which was 74.33 卤7.68mm, 7.06 卤1.85 卤10.47 卤1.299.17 卤2.139.80 卤2.45, respectively. There were significant differences between the patients with different degrees of systolic blood pressure, the systolic pressure level and the coefficient of variation of systolic blood pressure (SBP). Conclusion the increase of BP in age is the risk factor of WML, and long term BPV can predict the occurrence and progression of WML.
【作者单位】：苏州大学附属第一医院神经内科;连云港市第二人民医院神经内科;
【基金】：连云港市科技局社会发展项目(No.SH1538)
【分类号】：R742

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