重症肌无力伴胸腺瘤或胸腺增生的临床特征及预后

发布时间：2018-03-20 19:00

  本文选题：胸腺瘤　切入点：胸腺增生　出处：《中国康复理论与实践》2017年12期 　论文类型：期刊论文

【摘要】：目的分析伴胸腺瘤或胸腺增生的重症肌无力患者临床特点及预后。方法回顾性分析2007年1月至2016年12月伴胸腺瘤重症肌无力患者118例和伴胸腺增生重症肌无力患者42例,统计并比较两组发病年龄、性别、首发症状、临床分型、受累肌群、肌无力危象、低频重复神经电刺激及完全稳定缓解资料。结果与伴胸腺增生重症肌无力患者相比,伴胸腺瘤重症肌无力患者平均发病年龄大,Ⅲ型比例高,术后完全稳定缓解率低(P0.05),更易发生呼吸肌受累(χ~2=6.364,P=0.011)及肌无力危象(χ~2=5.455,P=0.022)。不同病理分型胸腺瘤伴发的重症肌无力患者之间呼吸肌受累(χ~2=8.532,P=0.036)和肌无力危象(χ~2=8.956,P=0.030)发生率存在显著性差异,以B3型最高,A+AB型最低。伴胸腺瘤重症肌无力患者重复神经电刺激阳性率高于伴胸腺增生重症肌无力患者,但无显著性差异(χ~21.357,P0.05);不同病理分型胸腺瘤重症肌无力患者有上升趋势,但无显著性差异(χ~26.623,P0.05)。结论伴胸腺瘤重症肌无力多见于中老年人,临床症状重,易有呼吸肌受累和肌无力危象,伴胸腺增生重症肌无力更能从手术中获益。重症肌无力低频重复神经电刺激阳性率与胸腺病变类型无明显关联。重症肌无力呼吸肌受累和肌无力危象与胸腺瘤病理分型有关。
[Abstract]:Objective to analyze the clinical characteristics and prognosis of myasthenia gravis patients with thymoma or thymic hyperplasia. Methods from January 2007 to December 2016, 118 patients with thymoma myasthenia gravis and 42 patients with thymic hyperplasia myasthenia gravis were retrospectively analyzed. The age, sex, initial symptom, clinical type, muscle group, myasthenia crisis, low frequency repetitive nerve stimulation and complete stable remission of the two groups were statistically analyzed and compared with those of the patients with thymic hyperplasia myasthenia gravis. The average age of myasthenia gravis patients with thymoma was older and the proportion of type 鈪，

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