抗神经元抗体相关的中枢神经系统疾病
发布时间:2018-03-20 19:54
本文选题:边缘叶脑炎 切入点:抗N-甲基-D-天冬氨酸受体脑炎 出处:《细胞与分子免疫学杂志》2016年11期 论文类型:期刊论文
【摘要】:抗神经元抗体是一组作用于神经元的抗体,这些抗体通常发现于某些特殊的中枢神经系统疾病如边缘叶脑炎、抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎、僵人综合征、Morvan综合征等患者的血清和(或)脑脊液中。这些抗体的发现为许多中枢神经系统疾病发病机制的研究提供了新的视角,并且为这些疾病的治疗提供了新的方向,在很大程度上改变了这些疾病的预后。并且,随着检测方法的不断提高,新发现的抗体种类不断增加,抗神经元抗体相关的中枢神经系统疾病谱也随之扩大。因此,我们对这些抗体相关的中枢神经系统疾病进行综述,以期为基础研究及临床工作提供一定的指导。
[Abstract]:Anti-neuronal antibodies are a set of antibodies acting on neurons that are commonly found in specific central nervous system diseases such as marginal lobe encephalitis and anti-NMDAR encephalitis. The discovery of these antibodies in serum and / or cerebrospinal fluid of patients such as Morvan's syndrome provides a new perspective for the study of the pathogenesis of many central nervous system diseases and provides a new direction for the treatment of these diseases. The prognosis of these diseases has been greatly changed. And with the improvement of detection methods, the types of newly discovered antibodies have been increasing, and the spectrum of central nervous system diseases associated with anti-neuronal antibodies has also expanded. We review these antibody-related central nervous system diseases in order to provide guidance for basic research and clinical work.
【作者单位】: 中南大学湘雅医院神经内科;
【基金】:国家自然科学基金(81271325)
【分类号】:R741
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