血清resistin、ox-LDL、hs-CRP在缺血性脑血管病发病机制中的作用及临床意义

发布时间：2018-03-20 20:45

本文选题：血清抵抗素　切入点：氧化型低密度脂蛋白　出处：《中国地方病防治杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨血清抵抗素(resistin)、氧化型低密度脂蛋白(ox-LDL)及超敏C反应蛋白(hs-CRP)在脑血管病发病机制中的作用及临床意义。方法缺血性脑血管患者91例为观察组,28例可逆性缺血性脑损伤患者(RIBD组)、36例短暂性脑缺血发作患者(TIA组)、27例局限性脑梗塞患者(FCI组),选同期健康志愿者71例为对照组。对比各组血清resistin、ox-LDL、hsCRP水平,并分析其与脑血管病严重程度相关性。结果 FCI、RIBD、TIA组血清resistin、ox-LDL、hs-CRP水平明显高于对照组(P0.05);RIBD、FCI组resistin、ox-LDL、hs-CRP水平明显高于TIA组(P0.05);Spearman相关分析显示血清resistin、ox-LDL、hs-CRP水平与脑血管严重程度呈正相关性(r_1=0.902,P_1=0.010;r_2=0.765,P_2=0.010;r_3=0.829,P_3=0.000)。结论血清resistin、ox-LDL、hs-CRP水平与脑血管病严重程度相关,并参与脑血管病的发生与发展。
[Abstract]:Objective to investigate the role and clinical significance of serum resistin, oxidized low density lipoprotein (ox-LDL) and hypersensitive C-reactive protein hs-CRP in the pathogenesis of cerebrovascular diseases. In the RIBD group, there were 36 patients with transient ischemic attack in TIA group and 27 patients with focal cerebral infarction in FCI group. 71 healthy volunteers were selected as control group. The serum levels of resistinin-ox-LDLhsCRP were compared in each group. Results the level of serum resistininox-LDLhs-CRP in TIA group was significantly higher than that in control group (P0.05). The level of hs-CRP in FCI group was significantly higher than that in TIA group (P0.05) and Spearman correlation analysis showed that the level of serum resistinin-LDLhs-CRP was positively correlated with the severity of cerebrovascular disease. The level of serum resistinox-LDLhs-CRP was correlated with the severity of cerebrovascular disease. And participate in the occurrence and development of cerebrovascular disease.
【作者单位】：滨州市人民医院;
【基金】：滨州市科技发展计划项目(编号:2015ZC1698)
【分类号】：R743

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