血清成纤维细胞生长因子23、Klotho蛋白水平与急性脑梗死患者颈动脉粥样硬化和脑卒中危险因素的相关性

发布时间：2018-03-22 13:48

本文选题：成纤维细胞生长因子　切入点：Klotho蛋白　出处：《中风与神经疾病杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨血清成纤维细胞生长因子23(FGF23)、Klotho蛋白水平与急性脑梗死患者颈动脉粥样硬化和脑卒中危险因素的相关性。方法入选166例急性脑梗死患者作为研究组,随机匹配152例健康为对照组,对血脂、同型半胱氨酸、C反应蛋白等指标进行采集,采用ELISA法测定各组血清中FGF23和Klotho蛋白水平,颈动脉As用多普勒超声仪检测,并与正常对照组进行比较。应用多因素Logistic回归对血清中FGF23水平与其他观察指标的相关性及影响因素进行分析。结果研究组tHcy、hs-CRP、FGF23水平显著高于对照组(P0.05),而HDL-C、Klotho蛋白水平显著低于对照组(P0.05),TC、LDL-C、TG与对照组相比统计学差异不显著(P0.05)。研究组的颈动脉As的比率、斑块数、斑块评分及IMT显著高于正常对照组(P0.05)。以颈动脉As情况为因变量,进行多因素非条件Logistic回归分析显示,hs-CRP、tHcy、FGF23为颈动脉As的危险因素,而HDL-C、Klotho蛋白为颈动脉As的保护因素。相关性分析显示,血FGF23水平与hs-CRP、tHcy、及颈动脉As斑块评分、IMT呈正相关(均P0.05);而与Klotho蛋白、HDL-C呈负相关(均P0.05)。结论 FGF23为动脉粥样硬化及脑梗死发生的危险因素,而Klotho蛋白则为动脉粥样硬化及脑梗死发生的保护因素,二者呈负相关。
[Abstract]:Objective to investigate the relationship between serum fibroblast growth factor 23 FGF23 Klotho protein and carotid atherosclerosis and stroke risk factors in patients with acute cerebral infarction. Methods 166 patients with acute cerebral infarction were selected as the study group. Blood lipids and homocysteine C-reactive protein were collected. Serum FGF23 and Klotho protein levels were measured by ELISA method. Carotid artery as was detected by Doppler ultrasound. Multivariate Logistic regression was used to analyze the correlation between serum FGF23 level and other observed indexes and its influencing factors. Results the level of tHcyhs-CRPfGF23 in the study group was significantly higher than that in the control group (P 0.05), while the level of HDL-Cn Klotho protein in the study group was significantly higher than that in the control group. Compared with the control group, there was no significant difference in TG between the control group and the control group (P 0.05). The ratio of as in the carotid artery in the study group was significantly lower than that in the control group. Plaque number, plaque score and IMT were significantly higher than those in normal control group (P 0.05). Multivariate Logistic regression analysis showed that hs-CRPtHcyFGF23 was a risk factor for carotid as. HDL-Con Klotho protein was the protective factor of carotid as. Correlation analysis showed that, Serum FGF23 level was positively correlated with hs-CRPtHcyT and carotid as plaque score (all P0.05%), but negatively correlated with HDL-C of Klotho protein (all P0.050.Conclusion FGF23 is a risk factor for atherosclerosis and cerebral infarction. Klotho protein was the protective factor of atherosclerosis and cerebral infarction.
【作者单位】：包头医学院第一附属医院神经内科;包头医学院研究生学院;
【分类号】：R743.33

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