丁苯酞治疗大面积脑梗死的临床观察

发布时间：2018-03-22 19:45

本文选题：丁苯酞　切入点：大面积脑梗死　出处：《中国新药杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:评价丁苯酞治疗大面积脑梗死患者的疗效及安全性。方法:前瞻性入选2015年1月至2015年12月在大连医科大学附属第一医院神经内科住院治疗的80例大面积脑梗死患者,随机分为丁苯酞治疗组(n=42)和对照组(n=38),记录并比较两组治疗前及治疗后d 8,d 15,d 30和d 90的NIHSS评分、BI指数,90 d改良RANKIN量表(mRS)评分、病死例数,计算治疗后d 8,d 15,d 30和d 90的治疗有效率。结果:丁苯酞治疗组和对照组d 30和d 90的NIHSS评分、BI指数,d 90的治疗有效率有统计学差异(P0.05)。丁苯酞治疗组和对照组治疗后d 90的良好结局比率分别为45.2%和15.8%,差异有统计学意义(χ2=8.05,P0.05);90 d病死率分别为2.4%(1/42)和18.4%(7/38),差异有统计学意义(P0.05)。丁苯酞治疗组和对照组不良事件发生率分别为9.5%(4例)和5.3%(2例),差异无统计学意义(P=0.766)。结论:丁苯酞治疗大面积脑梗死患者安全有效。
[Abstract]:Objective: to evaluate the efficacy and safety of butyphthalide in the treatment of large area cerebral infarction. Methods: 80 patients with large area cerebral infarction were enrolled prospectively in Department of Neurology, first affiliated Hospital of Dalian Medical University from January 2015 to December 2015. The patients were randomly divided into butyphthalide treatment group (n = 42) and control group (n = 38). The NIHSS scores were recorded and compared between the two groups before and after treatment on the 8th day, 15th day, 30 d and 90 d after treatment. Results: there were significant differences in the effective rates of the NIHSS scores of day 30 and day 90 between the butyrophthalide treatment group and the control group and the treatment rate of the BI index of the day 30 and 90. There was a significant difference between the butyrophthalide treatment group and the control group (P < 0.05). The good outcome rates of 90 days after treatment were 45.2% and 15.8%, respectively, and the difference was statistically significant (蠂 2 + 8.05%, P 0.05% 90 d mortality was 2.44% / 42) and 18.4% -38%, respectively. The difference was statistically significant (P 0.05). The incidence of adverse events in the butyphthalide treatment group and the control group was 9.55% and 5.3%, respectively. Conclusion: butyphthalide is safe and effective in the treatment of large area cerebral infarction.
【作者单位】：大连医科大学附属第一医院;保定市第一中心医院;
【分类号】：R743.33

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