不同CISS分型脑梗死患者血清神经元特异性烯醇化酶表达水平的临床意义

发布时间：2018-03-24 01:24

本文选题：神经元特异性烯醇化酶　切入点：中国缺血性卒中亚型　出处：《浙江实用医学》2016年05期

【摘要】：目的探讨不同CISS分型的急性脑梗死患者血清神经元特异性烯醇化酶(NSE)表达水平的临床意义。方法通过CISS分型将106例急性脑梗死患者分成不同亚组,进行NIHSS评分,并测定血清NSE水平,另选择99例体检健康者作为对照组,分析各亚组之间NSE水平差异以及NSE与NIHSS评分之间的关系。结果血清NSE含量以心源性脑梗死(CS)型最高,其次为不明原因性脑梗死(UND)型、其他病因明确性脑梗死(OE)型及大动脉粥样硬化性脑梗死(LAA)型,穿支动脉闭塞性脑梗死(PAD)型最低,而NIHSS评分亦以CS型最高,其次为LAA型、UND型及OE型,PAD型最低,与临床高度一致,血清NSE水平与NIHSS评分呈正相关(r=0.463,P0.01)。结论血清NSE水平能够反映不同病因脑梗死的病情严重程度,可以作为评估急性脑梗死病情和预后的简便敏感的血清学指标之一,与NIHSS评分相结合,结果更可靠。
[Abstract]:Objective to investigate the clinical significance of serum neuron-specific enolase (NSE) expression in patients with acute cerebral infarction according to different CISS classification. Methods 106 patients with acute cerebral infarction were divided into different subgroups by CISS classification and NIHSS scores were evaluated. Serum NSE levels were measured and 99 healthy persons were selected as control group. The difference of NSE level and the relationship between NSE and NIHSS score were analyzed. Results the serum NSE level was the highest in patients with cardiogenic cerebral infarction. The second type was unexplained cerebral infarction (NIHSS), the other type of definite cerebral infarction (OE), the type of atherosclerotic cerebral infarction (ACI) and the type of arteriosclerotic cerebral infarction (ICA) were the lowest, and the NIHSS score was the highest in type CS. Secondly, LAA type UND and OE type of pad type were the lowest, which was highly consistent with clinical data. Serum NSE level was positively correlated with NIHSS score (P 0.01). Conclusion Serum NSE level can reflect the severity of cerebral infarction with different etiological factors. It can be used as a simple and sensitive serological index to evaluate the condition and prognosis of acute cerebral infarction. Combined with NIHSS score, the result is more reliable.
【作者单位】：嘉兴市第一医院;
【基金】：浙江省嘉兴市医学重点学科(神经病学)资助(04-F-12)
【分类号】：R743.33

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