可降解镁合金覆膜支架治疗兔颈总动脉侧壁型动脉瘤可行性研究

发布时间：2018-03-28 16:25

  本文选题：可降解镁合金覆膜支架　切入点：Willis覆膜支架　出处：《介入放射学杂志》2016年02期

【摘要】：目的评价可降解镁合金覆膜支架治疗兔颈总动脉侧壁型动脉瘤的可行性。方法 20只新西兰大白兔饲养1周后采用间断式外翻缝合法将右侧颈总动脉与静脉囊吻合,构建20枚颈总动脉侧壁型动脉瘤。72 h内分别实施可降解镁合金覆膜支架植入术和Willis覆膜支架植入术。术前、术后即刻、术后3、6、12个月作DSA造影检查,对比动脉瘤闭塞、内漏、血管痉挛、血管损伤、血栓事件、血管闭塞和狭窄等情况。结果可降解镁合金覆膜支架和Willis覆膜支架各植入10枚,技术成功率为100%。支架植入术后即刻造影显示所有动脉瘤腔完全闭塞,载瘤动脉通畅,可降解镁合金覆膜支架组血管痉挛3例,Willis覆膜支架组血管痉挛1例;术后3、6、12个月复查造影显示动脉瘤完全消失,载瘤动脉通畅。结论可降解镁合金覆膜支架治疗兔颈总动脉侧壁型动脉瘤是可行的。
[Abstract]:Objective to evaluate the feasibility of degradable magnesium alloy coated stent in the treatment of lateral wall aneurysms of common carotid artery in rabbits. Methods Twenty New Zealand white rabbits were raised for 1 week to anastomose the right common carotid artery with the venous sac by intermittent valgus suture. Twenty common carotid artery lateral wall aneurysms were implanted with degradable magnesium alloy stent and Willis stent respectively within 72 hours. DSA angiography was performed immediately before, immediately after operation, and 12 months after operation, and compared with occlusion and internal leakage of aneurysm. Vasospasm, vascular injury, thrombotic events, vascular occlusion and stenosis. Results 10 biodegradable magnesium alloy coated stents and 10 Willis coated stents were implanted. The technical success rate was 100%. Immediately after stent implantation, all aneurysms were completely occluded, aneurysm carrying arteries were unobstructed, and 3 cases of vasospasm were found in the degradable magnesium alloy coated stent group, 1 case in the Willis covered stent group. The results showed that the aneurysm disappeared completely and the aneurysm was unobstructed. Conclusion it is feasible to treat the lateral wall aneurysm of the common carotid artery with degradable magnesium alloy stent.
【作者单位】： 苏州大学医学部;上海交通大学附属第六人民医院介入影像科;
【基金】：国家自然科学基金(81201199)
【分类号】：R743
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本文编号：1677112