尿激酶静脉溶栓治疗急性轻型缺血性脑卒中疗效观察

发布时间：2018-03-29 16:31

  本文选题：脑卒中　切入点：缺血性脑卒中　出处：《山东医药》2017年31期

【摘要】：目的观察尿激酶静脉溶栓治疗急性轻型缺血性脑卒中的疗效。方法将90例发病6 h内的急性轻型缺血性脑卒中患者随机分为观察组40例和对照组50例。观察组患者入院后给予尿激酶100万单位溶于200 mL生理盐水中静滴,24 h后复查头颅影像学排除脑出血,然后给予阿司匹林100 mg/d长期口服治疗。对照组患者入院后立即给予阿司匹林100 mg/d长期口服治疗。记录两组患者治疗前、治疗后14 d的美国国立卫生院卒中量表评分(NIHSS评分)及治疗后90 d NIHSS评分≤1分患者例数、改良Rankin量表评分(mRS评分)≤2分患者例数,另记录两组治疗后90 d内症状性颅内出血(SICH)、复发及死亡情况。结果观察组治疗前、治疗14 d后NIHSS评分分别为(2.94±0.60)、(1.6±0.92)分,对照组分别为(2.97±0.73)、(2.17±0.53),两组治疗14 d后NIHSS评分均低于治疗前,且治疗14 d后观察组NIHSS评分低于对照组(P均0.05)。治疗后90 d观察组NIHSS评分≤1分31例(77.5%),mRS评分≤2分32例(80%);对照组分别为23例(46%)和27例(54%);治疗后90 d观察组NIHSS评分≤1分者、mRS评分≤2分者均高于对照组(P均0.05)。治疗后90 d内两组均无SICH、死亡者;观察组2例(5.0%)、对照组9例(18%)复发,两组比较,P0.05。结论尿激酶静脉溶栓治疗急性轻型缺血性脑卒中有效,并且可以减少卒中的复发。
[Abstract]:Objective to observe the efficacy of intravenous thrombolysis with urokinase in the treatment of acute mild ischemic stroke. Methods 90 patients with acute mild ischemic stroke within 6 hours were randomly divided into observation group (n = 40) and control group (n = 50). Patients were treated with urokinase 1 million units dissolved in 200ml saline for 24 hours. The patients in the control group were treated with aspirin for a long period of time immediately after admission. The patients in both groups were recorded before treatment. The number of patients with National Institutes of Health Stroke scale (NHS) and 90 days after treatment (NIHSS score 鈮，

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