纤溶酶联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效观察

发布时间：2018-04-02 00:10

本文选题：急性脑梗死　切入点：纤溶酶　出处：《实用中西医结合临床》2016年10期

【摘要】：目的:观察纤溶酶联合丁苯酞氯化钠注射液对溶栓时间窗外脑梗死患者血流变及微循环状态的影响和临床疗效。方法:按照随机数字表法将90例脑梗死患者随机分为观察组和对照组,每组45例。在基础治疗的基础上,对照组采用纤溶酶治疗,观察组采用纤溶酶联合丁苯酞氯化钠注射液。治疗前后观测大脑中动脉的峰流速(Vp)、平均流速(Vm)的变化情况以及血流变、微循环状态、NIHSS评分变化和用药安全性指标。结果:同组血流变、微循环状态、Vp、Vm、NIHSS评分治疗前后比较差异有统计学意义(P0.05);观察组血流变、微循环状态、Vp、Vm、NIHSS评分均优于对照组(P0.05)。两组患者的用药安全性指标治疗前后均在正常范围内。结论:纤溶酶联合丁苯酞氯化钠注射液可有效改善脑梗死患者血流变、微循环状态、相关血液观察指标和血流动力学,提高急性脑梗死患者的临床疗效,有较高的临床应用价值。
[Abstract]:Objective: to observe the effect of fibrinolytic enzyme combined with butyphthalide sodium chloride injection on hemorheology and microcirculation in patients with cerebral infarction outside thrombolytic time window.Methods: 90 patients with cerebral infarction were randomly divided into observation group and control group with 45 cases in each group.On the basis of basic treatment, the control group was treated with fibrinolytic enzyme, the observation group was treated with fibrinolytic enzyme combined with butyphthalide sodium chloride injection.Before and after treatment, the changes of peak velocities and mean velocities of the middle cerebral artery (MCA), the changes of hemorheology, the changes of NIHSS score and the safety index of drug use were observed before and after treatment.Results: in the same group, the blood rheology, the microcirculation state and the VpP / VmN NIHSS score were significantly different before and after treatment, and the blood rheology and microcirculatory VMNIHSS scores in the observation group were better than those in the control group (P 0.05).The drug safety indexes of both groups were within normal range before and after treatment.Conclusion: fibrinolytic enzyme combined with butyphthalide sodium chloride injection can effectively improve the blood rheology, microcirculation, related blood indexes and hemodynamics in patients with acute cerebral infarction, and improve the clinical efficacy of the patients with acute cerebral infarction.It has high clinical application value.
【作者单位】：河南省洛阳市第一人民医院;河南省洛阳市中心医院;
【分类号】：R743.33

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