注射用红花黄色素联合阿加曲班治疗急性脑梗死的临床研究

发布时间：2018-04-02 04:20

本文选题：注射用红花黄色素　切入点：阿加曲班注射液　出处：《现代药物与临床》2016年02期

【摘要】：目的探讨注射用红花黄色素联合阿加曲班治疗急性脑梗死的临床疗效。方法选取2014年9月—2015年9月西安医学院第二附属医院收治的急性脑梗死患者96例,依据不同治疗方案分为治疗组和对照组,每组各48例。所有患者均给予降低颅内压、营养神经、调节血脂等基础治疗。对照组在此基础上给予阿加曲班注射液,第1~2天,阿加曲班注射液60mg加入生理盐水500 m L,24 h持续泵入;其后5 d,阿加曲班注射液10 mg加入生理盐水100 m L,3 h持续泵入,2次/d,第8~14天,1次/d。治疗组在对照组的基础上滴注注射用红花黄色素,100 m L/次,1次/d。两组均连续治疗2周。观察两组临床疗效,同时比较两组神经功能缺损量表(NIHSS)评分、Barthel指数、血液流变学指标和血管内皮功能及炎症因子变化情况。结果治疗后,对照组和治疗组总有效率分别为77.08%、91.67%,两组比较差异有统计学意义(P0.05)。治疗后,两组血浆黏度、全血黏度、红细胞压积(HCT)以及红细胞聚集指数(RF)均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组这些观察指标显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组NIHSS评分均降低,Barthel指数均升高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗2周后治疗组这些观察指标显著好于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组一氧化氮(NO)、内皮素-1(ET-1)、白细胞介素-8(IL-8)和肿瘤坏死因子α(TNF-α)表达水平均较治疗前明显改善,同组治疗前后比较差异具有统计学意义(P0.05);且治疗2周后治疗组这些观察指标显著好于对照组,两组比较差异具有统计学意义(P0.05)。结论注射用红花黄色素联合阿加曲班治疗急性脑梗死具有较好的临床疗效,能明显改善患者的血液流变学指标和血管内皮功能,具有一定的临床推广应用价值。
[Abstract]:Objective to investigate the clinical effect of safflower yellow pigment combined with agaltreban for injection in the treatment of acute cerebral infarction.Methods 96 patients with acute cerebral infarction treated in the second affiliated Hospital of Xi'an Medical College from September 2014 to September 2015 were divided into treatment group (n = 48) and control group (n = 48).All patients were treated with basic treatment such as reducing intracranial pressure, nourishing nerves and regulating blood lipids.The control group was given Agatripine injection on this basis. On the 1st day of 2 days, 60mg was continuously pumped into the control group for 24 h with normal saline (500m L / L).After 5 days, 10 mg of agatoban injection was injected with 100 mL normal saline for 3 h and pumped continuously for 2 times per day, and once per day on day 814.On the basis of the control group, the treatment group was injected with safflower yellow pigment 100 mL / once a day.The two groups were treated continuously for 2 weeks.The clinical efficacy of the two groups was observed, and the changes of Barthel index, hemorheology index, vascular endothelial function and inflammatory factors were compared between the two groups.Results after treatment, the total effective rates of the control group and the treatment group were 77.08 and 91.67, respectively. The difference between the two groups was statistically significant (P 0.05).After treatment, plasma viscosity, whole blood viscosity, hematocrit HCT (HCT) and erythrocyte aggregation index (RFRF) of the two groups were significantly lower than those of the control group, and the difference between the two groups before and after treatment was statistically significant (P 0.05), and after treatment these indexes in the treatment group were significantly lower than those in the control group.The difference between the two groups was statistically significant (P 0.05).After treatment, the NIHSS scores of the two groups were significantly lower than those of the control group, and the difference between the two groups before and after treatment was statistically significant (P 0.05), and after 2 weeks of treatment, these indexes in the treatment group were significantly better than those in the control group, and the difference between the two groups was statistically significant.After treatment, the expression levels of nitric oxide, endothelin-1, interleukin-8 (IL-8) and tumor necrosis factor 伪 (TNF- 伪) in both groups were significantly improved compared with those before treatment.The difference before and after treatment in the same group was statistically significant (P 0.05), and the observation index in the treatment group was significantly better than that in the control group after 2 weeks of treatment, and the difference between the two groups was statistically significant (P 0.05).Conclusion the combination of safflower yellow and agatoban for injection has a good clinical effect on acute cerebral infarction. It can obviously improve the hemorheological index and vascular endothelial function of the patients, and has a certain clinical application value.
【作者单位】：西安医学院第二附属医院神经内科;
【分类号】：R743.3

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