中药联合加巴喷丁治疗原发性三叉神经痛临床疗效观察

发布时间：2018-04-05 07:16

本文选题：中药　切入点：加巴喷丁　出处：《中华中医药学刊》2017年02期

【摘要】：目的:观察中药联合加巴喷丁治疗原发性三叉神经痛的临床疗效,指导临床治疗及用药。方法:220例原发性三叉神经痛患者随机分为观察组与对照组,每组各110例,观察组采用口服中药+加巴喷丁治疗,对照组采用加巴喷丁治疗,两组均治疗4周后,评价患者临床疗效,对比两组患者治疗前后VAS(视觉模拟评分)及PSQI(匹兹堡睡眠质量问卷)评分变化情况,并记录与治疗及用药相关的不良反应发生情况。结果:治疗后,观察组患者的总有效率为89.09%,高于对照组的75.45%,差异具有统计学意义(P0.05)。治疗后,两组患者VAS及PSQI评分水平均低于治疗前,其中观察组患者VAS及PSQI评分低于对照组,差异具有统计学意义(P0.05)。两组患者不良反应发生率相当,不具有统计学差异(P0.05)。结论:口服中药配合巴喷丁治疗原发性三叉神经痛临床疗效却轻,能够改善患者的睡眠质量,且安全性较好,值得临床推广使用。
[Abstract]:Objective: to observe the clinical effect of traditional Chinese medicine combined with gabapentine in the treatment of primary trigeminal neuralgia.Methods Twenty two hundred and twenty patients with primary trigeminal neuralgia were randomly divided into observation group (n = 110) and control group (n = 110).To evaluate the clinical efficacy, to compare the changes of Vas (visual analogue score) and PSQI (Pittsburgh Sleep quality questionnaire) before and after treatment, and to record the adverse reactions related to treatment and medication.Results: after treatment, the total effective rate of the patients in the observation group was 89.09, which was higher than that in the control group (75.45%). The difference was statistically significant (P 0.05).After treatment, the VAS and PSQI scores in the two groups were lower than those before treatment, and the VAS and PSQI scores in the observation group were lower than those in the control group (P 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05).Conclusion: oral Chinese medicine combined with bapentin has a mild clinical effect in the treatment of primary trigeminal neuralgia, which can improve the sleep quality of the patients, and is safe and worthy of clinical popularization.
【作者单位】：浙江大学医学院附属第一医院三门湾分院神经内科;
【分类号】：R745.11

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