脑梗死后血清基质金属蛋白酶-9水平变化及临床意义

发布时间：2018-04-05 11:23

本文选题：MMP-9　切入点：TOAST分型　出处：《皖南医学院》2014年硕士论文

【摘要】：目的：探讨血清MMP-9水平与脑梗死的关系，分析其与脑梗死病因的相关性，了解血清MMP-9水平的检测对评估脑梗死患者的病情及预后的临床意义。方法：选择发病后48小时内的急性脑梗死患者80例作为脑梗死组（CI组），经头颅CT或MRI检查确诊，随机分为TOAST分型中的大动脉粥样硬化性梗死组40例（LAA组），心源性脑栓塞组40例（CCE组），，另选择40例入院体检者作为对照组（C组）。于入院次日清晨空腹抽取静脉血，采用酶联免疫吸附（ELISA）法测定血清MMP-9水平。结果用SPSS17.0软件包进行统计学分析。结果：1.CI组患者血清MMP-9水平高于C组，两者差异具有统计学意义（P0.01）；2.LAA组患者血清MMP-9水平与CCE组差异无明显统计学意义（P0.05）；3.将CI组患者进行美国国立卫生院卒中量表（NIHSS）评分发现，血清MMP-9水平与NIHSS评分呈正相关（相关系数r=0.583，P0.01）；4.根据NIHSS评分分组比较血清MMP-9水平，差异有统计学意义（P0.01）；5.Logistic回归分析发现，MMP-9与脑梗死的多种因素具有相关性（回归系数β=1.513，P0.01）。结论：1.脑梗死组患者血清MMP-9水平较对照组明显升高，提示MMP-9可能参与了脑梗死的发病过程。2.大动脉粥样硬化性脑梗死与心源性脑栓塞患者血清MMP-9水平变化无明显差异。3.脑梗死患者血清MMP-9水平与神经功能缺损程度呈正相关，血清MMP-9水平可提示脑梗死患者的病情及预后。
[Abstract]:Objective: to investigate the relationship between serum MMP-9 level and cerebral infarction, to analyze the relationship between serum MMP-9 level and the etiology of cerebral infarction, and to understand the clinical significance of serum MMP-9 level in evaluating the condition and prognosis of patients with cerebral infarction.Methods: 80 patients with acute cerebral infarction within 48 hours after onset were selected as CI group and diagnosed by CT or MRI.The patients were randomly divided into TOAST classification group (n = 40), Atherosclerotic infarction group (n = 40), cardiogenic cerebral embolism group (n = 40) and control group C (n = 40).Venous blood was collected on an empty stomach the next day after admission and serum MMP-9 level was determined by Elisa.Results SPSS17.0 software package was used for statistical analysis.Results 1. The serum MMP-9 level in CI group was higher than that in C group, and the difference was statistically significant. 2. There was no significant difference in serum MMP-9 level between LAA group and CCE group.The stroke scale (NIHSS) score of CI group showed that the serum MMP-9 level was positively correlated with the NIHSS score (r = 0. 583, P 0. 01, P 0. 01).The serum MMP-9 levels were compared according to the NIHSS scores. 5. Logistic regression analysis showed that there was a correlation between MMP-9 and many factors of cerebral infarction (regression coefficient 尾 1. 513 + P 0. 01).Conclusion 1.The level of serum MMP-9 in cerebral infarction group was significantly higher than that in control group, suggesting that MMP-9 might be involved in the pathogenesis of cerebral infarction.There was no significant difference in serum MMP-9 levels between patients with atherosclerotic cerebral infarction and cardiogenic cerebral embolism.The level of serum MMP-9 was positively correlated with the degree of neurological impairment in patients with cerebral infarction, and the level of serum MMP-9 could indicate the condition and prognosis of patients with cerebral infarction.
【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.32

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