丁苯酞注射液联合依达拉奉对脑梗死损伤的保护作用

发布时间：2018-04-06 02:07

本文选题：脑梗死　切入点：丁苯酞注射液　出处：《医学综述》2016年24期

【摘要】：目的探讨丁苯酞注射液联合依达拉奉用药对脑梗死损伤的保护作用。方法选取2015年3月至2016年3月芜湖市第二人民医院收治的脑梗死患者60例,采用随机数字法分为对照组和观察组,各30例。对照组患者给予拜阿司匹林(100 mg/d)、依达拉奉(30 mg)加入0.9%氯化钠注射液100 m L,静脉滴注,每日2次;观察组在此基础上加用丁苯酞氯化钠注射液100 m L,静脉滴注,每日2次。两组疗程均为28 d。对比两组患者治疗前后美国国立卫生研究院脑卒中量表评分(NIHSS)、改良Barthel指数(MBI)评分,并比较两组治疗后的临床疗效。结果治疗后7、14、21、28 d,两组患者NIHSS均呈下降趋势,且观察组治疗后7、14、21、28 d NIHSS低于对照组,差异有统计学意义(P0.05)。治疗后7、14、21、28 d,两组患者MBI评分呈上升趋势,且观察组治疗后7、14、21、28 d MBI评分高于对照组,差异有统计学意义(P0.05)。观察组总有效率高于对照组[86.7%(26/30)比56.7%(17/30)],差异有统计学意义(P0.05)。结论丁苯酞注射液联合依达拉奉用药对脑梗死损伤具有良好的保护作用,临床疗效显著。
[Abstract]:Objective to investigate the protective effect of butyphthalide injection combined with Edaravone on cerebral infarction injury.Methods 60 patients with cerebral infarction admitted to Wuhu second people's Hospital from March 2015 to March 2016 were randomly divided into control group (n = 30) and observation group (n = 30).The patients in the control group were treated with Aspirin 100 mg / d, Edaravone 30 mg) and 0.9% sodium chloride injection 100 mL, intravenous drip, twice a day, while in the observation group, 100 mg / d of butyrophthalide sodium chloride injection was added to the treatment group, 2 times a day.The course of treatment in both groups was 28 days.The scores of NIHSS scale and modified Barthel index before and after treatment were compared between the two groups, and the clinical efficacy of the two groups was compared.Results after 7 days of treatment, the NIHSS of the two groups showed a downward trend, and the NIHSS of the observation group was lower than that of the control group on the 28th day after treatment, and the difference was statistically significant (P 0.05).After 7 days of treatment, the MBI score of the two groups showed an upward trend, and the MBI score of the observation group was higher than that of the control group on the 7th day after treatment, the difference was statistically significant (P 0.05).The total effective rate in the observation group was higher than that in the control group [86.7% 26 / 30] and the difference was statistically significant (P 0.05).Conclusion butyphthalide injection combined with Edaravone has a good protective effect on cerebral infarction injury.
【作者单位】：芜湖市第二人民医院神经内科;
【分类号】：R743.33

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