脑重大疾病的机理和诊治

发布时间：2018-04-14 03:28

本文选题：单细胞技术 + 非人灵长类模型　；参考：《中国科学院院刊》2016年07期

【摘要】：脑疾病是我国乃至全球人口健康领域正面临的重大挑战。尽快部署脑疾病研究的中长期战略具有重大意义,将显著提升我国在该领域的国际竞争力,促进相关学科的发展以及新技术和新治疗途径的开发,实现脑疾病的精准医疗。脑疾病的研究正在从分子细胞机理、介观网络机制、生物标记物与分子分型、影像诊断和治疗策略研发等多个层面推进,其中介观网络研究是当前脑科学研究的新焦点,将填补分子细胞机理和宏观疾病症状之间的鸿沟。基于脑疾病的复杂性,非人灵长类动物可能是研究人类脑疾病的最优模型,我国在该领域具有明显优势;而脑疾病的早期诊断和早期干预是脑疾病治疗的关键,我国有丰富的临床资源库,亟需建立国际规范化、全国统一化的采样、处理、分析标准和共享的规则。此外,单细胞和单分子技术是微观研究的新趋势,也是精准医疗的关键技术,在解析复杂脑疾病机理方面具有重要的价值。
[Abstract]:Brain disease is a major challenge in the field of population health in China and the world.It is of great significance to deploy the medium- and long-term strategy of brain disease research as soon as possible, which will significantly enhance our country's international competitiveness in this field, promote the development of related disciplines and new technologies and new treatment approaches, and realize the accurate medical treatment of brain diseases.The research of brain diseases is advancing from molecular cellular mechanism, mesoscopic network mechanism, biomarkers and molecular typing, imaging diagnosis and treatment strategy development, etc. The intermediary network research is the new focus of brain science research.Will bridge the gap between molecular cellular mechanisms and macro-disease symptoms.Because of the complexity of brain diseases, non-human primates may be the best model for the study of human brain diseases, and our country has obvious advantages in this field, and the early diagnosis and early intervention of brain diseases is the key to the treatment of brain diseases.There are abundant clinical resources in our country, it is urgent to establish international standardization, unified sampling, processing, analysis standards and shared rules.In addition, single cell and single molecule technology is a new trend of microcosmic research, and also a key technology of precision medicine, which has important value in understanding the mechanism of complex brain diseases.
【作者单位】：中国科学院上海生命科学研究院神经科学研究所;中国科学院昆明动物研究所;中国科学技术大学生命科学学院;
【基金】：中科院战略性先导科技专项项目(B类)(XDB0200000)
【分类号】：R741

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