肢体远隔缺血预适应对缺血性脑血管病患者血清脑源性神经营养因子和基质金属蛋白酶-9水平的影响

发布时间：2018-04-14 13:37

本文选题：肢体远隔缺血预适应 + 脑缺血　；参考：《中国老年学杂志》2017年09期

【摘要】：目的观察肢体远隔缺血预适应对缺血性脑血管病患者血清中脑源性神经营养因子(BDNF)和基质金属蛋白酶(MMP)-9的影响。方法既往有缺血性脑血管病(短暂性脑缺血发作或脑梗死)的患者,经药物规范治疗将危险因素控制在正常范围内,同时经影像学证实有血管狭窄患者98例随机分为两组,观察组应用肢体远隔缺血预适应的训练方法,对照组不进行此种干预。6个月后观察两组Barthel指数(BI)评分及生活质量评分、6个月内脑梗死的发生率,同时关注患者血清中BDNF和MMP-9的表达。结果观察组BI评分明显高于对照组,观察组再梗死的发生率明显低于对照组,观察组生活质量明显高于对照组,观察组血清中BDNF的表达明显高于对照组,观察组血清中MMP-9的表达明显低于对照组(均P0.05)。结论肢体远隔缺血预适应可以改善缺血性脑血管病患者的神经功能,减少再梗死率,改善患者生活质量,同时能改变血清中BDNF和MMP-9的表达,优化内环境。
[Abstract]:Objective to observe the effects of limb remote ischemic preconditioning on BDNF- and MMP-9 in serum of patients with ischemic cerebrovascular disease.Methods 98 patients with ischemic cerebrovascular disease (transient ischemic attack or cerebral infarction) were randomly divided into two groups.The patients in the observation group were treated with remote ischemic preconditioning, and the control group was not treated with this intervention. After 6 months, the Barthel index (BI) score and the quality of life (QOL) score of the two groups were observed, and the incidence of cerebral infarction within 6 months was observed.At the same time, the expression of BDNF and MMP-9 in the patient's serum was concerned.Results the BI score in the observation group was significantly higher than that in the control group, the incidence of re-infarction in the observation group was significantly lower than that in the control group, the quality of life in the observation group was significantly higher than that in the control group, and the expression of BDNF in serum of the observation group wasThe expression of MMP-9 in serum of the observation group was significantly lower than that of the control group (all P 0.05).Conclusion remote ischemic preconditioning can improve the neurological function, reduce the rate of re-infarction, improve the quality of life, change the expression of BDNF and MMP-9 in serum and optimize the internal environment in patients with ischemic cerebrovascular disease.
【作者单位】：锦州医科大学附属第一医院神经内科;锦州医科大学附属第二医院正畸科;
【分类号】：R743.3

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