脂蛋白相关磷脂酶A2和B型脑钠肽在急性缺血性脑卒中早期诊断中的价值

发布时间：2018-04-17 00:02

本文选题：缺血性脑卒中 + 脂蛋白相关磷脂酶A　；参考：《江苏医药》2016年23期

【摘要】：目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)、B型脑钠肽(BNP)在急性缺血性脑卒中早期诊断中的价值。方法选择急性缺血性脑卒中患者112例为病例组,57例健康者为对照组,测定血清Lp-PLA2、缺血修饰蛋白(IMA)、TC、TG、LDL-C、HDL-C、脂蛋白a[Lp(a)]及血浆D-二聚体(D-D)、BNP水平并进行统计分析。结果病例组Lp-PLA2、BNP、IMA、LDL-C、Lp(a)、D-D水平高于对照组,HDL-C水平低于对照组(P0.05);两组TC、TG水平差异无统计学意义(P0.05)。多因素Logistic回归分析显示,吸烟、糖尿病、Lp-PLA2、BNP、IMA、HDL-C为急性缺血性脑卒中的独立影响因素(P0.05)。Spearman秩相关分析显示,血清Lp-PLA2水平与LDL-C、Lp(a)、IMA、D-D水平和颈总动脉内中膜厚度(IMT)呈正相关(r=0.185、0.227、0.270、0.364和0.225,P0.05),与HDL-C呈负相关(r=-0.280,P0.01);血浆BNP水平与IMA和IMT呈正相关(r=0.201和0.217,P0.05)。结论 Lp-PLA2和BNP参与急性缺血性脑卒中的病理生理过程。
[Abstract]:Objective to investigate the value of serum lipoprotein associated phospholipase A 2 (Lp-PLA 2) B type brain natriuretic peptide (BNP) in the early diagnosis of acute ischemic stroke.Methods A total of 112 patients with acute ischemic stroke were selected as control group and 57 healthy controls. The levels of serum Lp-PLA2, Ischemia-modified protein TGG, LDL-C, lipoprotein a and plasma D-dimer D-DU BNP were measured and analyzed statistically.Results the level of Lp-PLA2BNPAIMA LDL-CU D-D was higher than that of the control group (P 0.05), but there was no significant difference between the two groups in the level of TCU TG (P0.05P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05).Multivariate Logistic regression analysis showed that smoking and diabetes mellitus (Lp-PLA2) BNP-IMAL-C were independent influencing factors of acute ischemic stroke (P 0.05n. Spearman rank correlation analysis).The level of serum Lp-PLA2 was positively correlated with the level of IMA D-D and IMT of the common carotid artery, and negatively correlated with HDL-C. The level of plasma BNP was positively correlated with IMA and IMT.Conclusion Lp-PLA2 and BNP are involved in the pathophysiological process of acute ischemic stroke.
【作者单位】：南通市第二人民医院检验科;
【分类号】：R743.3;R446.1

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