急性脑梗死早期血中miRNAs水平与脑侧支循环建立的关系

发布时间：2018-04-17 17:44

本文选题：急性脑梗死 + 侧支循环　；参考：《中风与神经疾病杂志》2016年02期

【摘要】：目的探讨急性脑梗死早期外周血清中miRNAs水平与侧支循环建立的关系及临床意义。方法选择2014年1月-2015年11月在我院住院的急性脑梗死患者,根据其脑侧支循环状况,分为侧支循环良好组(42例)与不良组(28例),另设31例健康体检者为对照。比较各组间一般临床资料及梗死早期血清中一组miRNAs的分子变化,并进一步用Logistic回归分析miRNAs水平与梗死患者侧支循环建立的关系。结果血清中抑制血管新生的MIR-15b、MIR-92a及促血管新生的MIR-126、MIR-132和MIR-210水平在侧支循环良好、不良组及对照组间存在差异表达,部分特异性miRNAs分子组间比较有显著性差异(P0.05,P0.01);Logistic回归显示,这些抑制或促血管新生的miRNAs,特别是促血管新生的MIR-126、MIR-132和MIR-210是急性脑梗死侧支循环建立好坏的影响因素。结论早期血清中一组特异性miRNAs分子可能作为一种预测急性脑梗死患者脑内侧支循环状况的便捷指标。
[Abstract]:Objective to investigate the relationship between serum miRNAs level and collateral circulation in the early stage of acute cerebral infarction and its clinical significance.Methods patients with acute cerebral infarction who were hospitalized in our hospital from January 2014 to November 2015 were divided into two groups according to their collateral circulation: good collateral circulation group (n = 42) and bad group (n = 28).The general clinical data and the molecular changes of miRNAs in the early stage of infarction were compared, and the relationship between the level of miRNAs and collateral circulation in patients with infarction was further analyzed by Logistic regression analysis.Results the levels of MIR-15btr MIR-92a in serum and MIR-126U MIR-132 and MIR-210 in serum were good in collateral circulation, and there were differences between the poor group and the control group. There was a significant difference between the partial specific miRNAs molecule group and the partial specific miRNAs molecule group, and the logistic regression analysis showed that there was no significant difference between the two groups.These inhibiting or promoting angiogenic miRNAss, especially MIR-126 MIR-132 and MIR-210, are the factors influencing the establishment of collateral circulation in patients with acute cerebral infarction.Conclusion A group of specific miRNAs molecules in early serum may be a convenient index for predicting the status of medial cerebral collateral circulation in patients with acute cerebral infarction.
【作者单位】：上海市浦东新区公利医院中法合作中心实验室;上海市浦东新区公利医院神经科;
【基金】：国家自然科学基金面上项目(No.81171244;No.81571203) 上海市自然科学基金项目(No.15ZR1437200) 上海市浦东新区卫生系统重点学科建设资助(No.PWZx2014-08);上海市浦东新区卫生系统领先人才培养计划(No.PWR12014-05) 上海市浦东新区科技发展基金(No.PKJ2014-Y21) 上海市医学重点专科建设计划项目(No.ZK2015B16)
【分类号】：R743.33

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