MACROD2基因rs2208454单核苷酸多态性与脑出血的关系研究

发布时间：2018-04-17 20:30

本文选题：脑出血 + rs　；参考：《临床神经病学杂志》2017年01期

【摘要】：目的研究MACROD2基因rs2208454单核苷酸多态性与脑出血(ICH)的关系。方法采用SNa Pshot方法检测124例ICH患者(ICH组)及149名正常对照者(对照组)的rs2208454单核苷酸多态性。结果与对照组比较,ICH组及脑叶出血亚组收缩压、舒张压及高血压史、糖尿病史比率显著增高(均P0.05),非脑叶出血亚组收缩压、舒张压及高血压史、糖尿病史、饮酒史比率显著增高(均P0.05)。与对照组比较,TT、GT、GG基因型分布在ICH组及其亚组差异均无统计学意义(均P0.05)。非条件Logistic回归分析显示,SNP rs2208454与ICH无相关性(均P0.05)。亚组分析中,SNP rs2208454与非脑叶出血及脑叶出血亦无相关性(均P0.05)。结论 rs2208454单核苷酸多态性与ICH不相关。
[Abstract]:Objective to study the relationship between MACROD2 gene rs2208454 single nucleotide polymorphism and intracerebral hemorrhage (ICH).Methods the single nucleotide polymorphisms of rs2208454 were detected by SNa Pshot in 124 patients with ICH and 149 normal controls (control group).Results compared with the control group, systolic blood pressure, diastolic blood pressure and history of hypertension were significantly increased in ICH group and lobar hemorrhage subgroup (all P 0.05), systolic blood pressure, diastolic blood pressure and hypertension history, diabetes history in non-cerebral hemorrhage subgroup were significantly higher than those in ICH group.The ratio of drinking history was significantly higher (all P 0.05).Compared with the control group, there was no significant difference in GG genotype distribution in ICH group and its subgroup (all P 0.05).Non-conditional Logistic regression analysis showed that there was no correlation between SNP rs2208454 and ICH (all P 0.05).In subgroup analysis, there was no correlation between SNP rs2208454 and non-lobar hemorrhage and lobar hemorrhage (all P 0.05).Conclusion rs2208454 single nucleotide polymorphism is not associated with ICH.
【作者单位】：扶绥县人民医院神经内科;广西医科大学第一附属医院神经内科;
【基金】：广西自然科学基金(2013GXNSFBA019131,2015GXNS FAA139171)
【分类号】：R743.34

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