脑卒中静息态下脑活动异常的比率低频振幅fMRI研究

发布时间：2018-04-18 22:30

本文选题：脑卒中 + 功能磁共振成像　；参考：《磁共振成像》2016年06期

【摘要】：目的运用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-f MRI)的比率低频振幅(fractional amplitude of low frequency fluctuation,f ALFF)方法探究慢性期脑卒中患者基线脑活动异常变化。材料与方法16例慢性期左侧皮层下病变脑卒中患者和16例年龄性别相匹配的健康志愿者均接受静息态功能磁共振扫描,在0.01~0.08 Hz频段内计算f ALFF值,运用双样本t检验(P0.05,Alpha Sim矫正)比较两组间的f ALFF差异。结果与健康对照组比较,脑卒中患者组f ALFF值显著降低区域主要位于病灶同侧丘脑和基底节区,其中丘脑的f ALFF值与患者临床手功能评分呈正相关(r=0.54,P=0.030.05)。结论脑卒中自发神经活动异常与病灶部位和病灶所致的手运动功能障碍密切相关,这些发现有助于进一步阐释脑卒中运动功能障碍的病理生理学机制。
[Abstract]:Objective to investigate the abnormal changes of baseline brain activity in patients with chronic stroke using resting state functional magnetic resonance imaging rs-f MRIs.Materials and methods Sixteen patients with chronic left subcortical lesion stroke and 16 age-matched healthy volunteers underwent resting functional magnetic resonance imaging (ffMRI) to calculate the f ALFF value in the frequency range of 0. 01 ~ 0. 08 Hz.The difference of f ALFF between the two groups was compared by using double sample t test (P 0.05 Sim correction).Results compared with the healthy control group, the decrease area of f ALFF in stroke patients was mainly located in the ipsilateral thalamus and basal ganglia. The f ALFF value of thalamus was positively correlated with the clinical hand function score.Conclusion the abnormal spontaneous nerve activity in stroke is closely related to the hand motor dysfunction caused by the lesion site and focus. These findings are helpful to further explain the pathophysiological mechanism of stroke motor dysfunction.
【作者单位】：华东师范大学物理系上海市磁共振重点实验室;中国科学院上海生命科学研究院灵长类神经生物学重点实验室;复旦大学附属华山医院康复科;
【基金】：国家自然科学基金面上项目(编号:81471651);国家自然科学基金青年项目(编号:81401859) 国家科技部“十二五”支撑计划项目(编号:2013BAI10B03)~~
【分类号】：R445.2;R743.3

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