脑梗塞复发的预测因素探讨

发布时间：2018-04-21 20:04

  本文选题：脑梗塞复发 + 预测因素　； 参考：《福建医科大学》2014年硕士论文

【摘要】：目的：脑梗塞复发率高，影响复发因素多，为了探讨脑梗塞复发可能的预测因素，我们选择高敏C-反应蛋白、内皮素-1、纤维蛋白原等常见因素，对脑梗塞进行为期二年的随访，以了解这几个因素预测脑梗塞复发的可能。 方法：选择在福建医科大学附属第二医院2011.09～2012.03住院的首次脑梗塞患者123例，在入院24小时内检查高敏C-反应蛋白、内皮素-1、纤维蛋白原，并对每位患者进行门诊随访2年，患者死亡或新的脑梗塞发生时，终止随访。 结果：经过2年的随访，，其中31例在2年随访内死亡或新的脑梗塞发生，复发率为25.2%。对31例复发的脑梗塞患者不同浓度高敏C-反应蛋白、内皮素-1、纤维蛋白原进行分层后，分别各自算出其复发率，P值均小于0.05，有显著性意义。再经过多元logistic回归分析表明高浓度高敏C-反应蛋白、内皮素-1、纤维蛋白原与患者死亡或新的脑梗塞发生有关。 结论：首次脑梗塞患者血清高敏C-反应蛋白、内皮素-1、纤维蛋白原浓度与脑梗塞复发有显著相关性，是首次脑梗塞患者复发的独立危险因素。
[Abstract]:Objective: the recurrence rate of cerebral infarction is high, and there are many factors affecting the recurrence. In order to explore the possible predictors of cerebral infarction recurrence, we chose Gao Min C-reactive protein, endothelin-1, fibrinogen and other common factors to follow up cerebral infarction for two years. To understand these factors to predict the recurrence of cerebral infarction. Methods: 123 patients with first cerebral infarction were selected from the second affiliated Hospital of Fujian Medical University. Gao Min C-reactive protein, endothelin-1 and fibrinogen were examined within 24 hours of admission, and each patient was followed up for 2 years. The follow-up was terminated when the patient died or a new cerebral infarction occurred. Results: after 2 years follow up, 31 cases died or new cerebral infarction occurred during 2 years follow-up, the recurrence rate was 25. 2%. After stratification of Gao Min C-reactive protein, endothelin-1 and fibrinogen in 31 patients with recurrent cerebral infarction, the recurrence rate (P < 0.05) was calculated respectively. Multiple logistic regression analysis showed that high concentrations of Gao Min C-reactive protein, endothelin -1 and fibrinogen were associated with death or new cerebral infarction. Conclusion: the serum concentration of Gao Min C-reactive protein, endothelin -1 and fibrinogen in patients with first cerebral infarction is significantly correlated with the recurrence of cerebral infarction, and is an independent risk factor for recurrence in patients with first cerebral infarction.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.33


本文编号：1783907