丁苯酞氯化钠注射液对急性脑梗死患者脑血流及神经功能的影响

发布时间：2018-04-24 16:28

  本文选题：急性脑梗死 + 丁苯酞氯化钠注射液　； 参考：《河北大学》2017年硕士论文

【摘要】：目的:观察丁苯酞氯化钠注射液对急性脑梗死患者治疗作用的机制,并探讨改善脑组织血流是否是丁苯酞治疗急性脑梗死的机制。方法:选取我院60例急性脑梗死患者,采取数字表法随机分为观察组和对照组各30例,两组患者均给予阿司匹林、阿托伐他汀等常规治疗,观察组在基础治疗上应用丁苯酞氯化钠注射液治疗,两组患者均连续治疗14天,观察两组治疗前后的疗效,并采用美国国立卫生研究院卒中量表(NIHSS)评价两组患者治疗前后的神经功能缺损状况。采用TCD屏气试验检测治疗前后脑血流情况,对比两组治疗前、治疗72小时、治疗7天、治疗14天的脉动指数(PI)、屏气指数(BHI)、平均血流速度(Vm)。结果:(1)观察组总有效率90%,对照组总有效率76.67%,观察组的总有效率明显高于对照组,差异有统计学意义(χ2=6.13,P0.01)。(2)治疗后两组患者NIHSS评分均显著降低,与对照组相比,观察组降低更明显(t=3.118,P0.05)。(3)两组患者治疗前的PI、BHI、Vm对比均,差异无统计学意义(P0.05),治疗后72小时、7天、14天两组患者的PI有不同程度降低,BHI和Vm不同程度增高,两组患者治疗14天的PI、BHI、Vm对比,差异有统计学意义(P0.05)。其中对照组治疗72小时、7天的PI、BHI、Vm与治疗前相比,差异无统计学意义(P0.05),治疗组治疗14天的PI、BHI、Vm与治疗前相比,差异有统计学意义(P0.05)。观察组治疗72小时的PI、BHI、Vm与治疗前相比,差异无统计学意义(P0.05),观察组治疗7天、14天的PI、BHI、Vm与治疗72小时相比,差异无统计学意义(P0.05),进一步两两比较,治疗72小时、7天的PI、BHI、Vm与治疗14天相比,差异有统计学意义(P0.05)。结论:丁苯酞氯化钠注射液用于急性脑梗死患者能够更好的改善患者的脑血流状况,减少患者的神经功能缺损,加快脑组织修复,对急性脑梗死的治疗有明显疗效,临床安全有效,且无明显不良反应,值得在临床上推广和应用。
[Abstract]:Objective: to observe the therapeutic effect of butyphthalide sodium chloride injection on patients with acute cerebral infarction and to explore whether improving the blood flow of brain tissue is the mechanism of butyphthalide in treating acute cerebral infarction. Methods: sixty patients with acute cerebral infarction in our hospital were randomly divided into observation group (n = 30) and control group (n = 30). The observation group was treated with butyphthalide sodium chloride injection in the basic treatment, and the two groups were treated continuously for 14 days. The curative effect of the two groups before and after treatment was observed. The National Institutes of Health Stroke scale (NIHSS) was used to evaluate the neurological impairment of the two groups before and after treatment. The cerebral blood flow before and after treatment was measured by TCD breath-holding test. The pulsation index (Pi), the breath-holding index (BHI), and the mean blood flow velocity (VMV) of 72 hours, 7 days and 14 days of treatment before and after treatment were compared between the two groups. Results the total effective rate was 90 in the observation group and 76.67 in the control group. The total effective rate in the observation group was significantly higher than that in the control group (蠂 ~ (2) 6.13) (P 0.01). The NIHSS scores of the two groups were significantly lower than those in the control group. There was no significant difference of Pi BHIV m between the two groups before treatment, there was no significant difference between the two groups. The Pi of the two groups increased in different degree after 72 hours, 7 days and 14 days after treatment, and the two groups had 14 days of treatment of PIBHIVm. The difference was statistically significant (P 0.05). In the control group, there was no significant difference in PIBHIVm between 72 hours and 7 days after treatment, but there was no significant difference between the treatment group and the treatment group after 14 days of treatment. There was a significant difference between the treatment group and the pre-treatment group (P 0.05). There was no significant difference in PIBHIVm between the observation group and the control group after 72 hours treatment (P 0.05), but there was no significant difference between the observation group and the 72 hours treatment group (P 0.05 vs 72 h), and there was no significant difference between the observation group and the 72 hours treatment group, and there was no significant difference between the observation group and the treatment group (P 0.05), and there was no significant difference between the observation group and the 72 hours treatment group (P 0.05). Compared with 14 days, the difference of PIBHIVm between 72 hours and 7 days was statistically significant (P 0.05). Conclusion: butyphthalide sodium chloride injection in patients with acute cerebral infarction can better improve the cerebral blood flow, reduce the neurological deficit of patients, accelerate the repair of brain tissue, and have obvious curative effect on the treatment of acute cerebral infarction. It is safe and effective in clinic and has no obvious adverse reaction, so it is worth popularizing and applying in clinic.
【学位授予单位】：河北大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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