Hcy、UA水平与脑梗死合并颈动脉粥样硬化斑块的关系

发布时间：2018-04-27 09:48

本文选题：脑梗死 + 颈动脉粥样硬化斑块　；参考：《兰州大学》2017年硕士论文

【摘要】：研究目的:研究Hcy、UA水平与脑梗死合并颈动脉粥样硬化斑块的相关性;研究Hcy、UA水平与脑梗死合并颈动脉粥样硬化斑块的斑块性质的关系。研究方法:随机选取并回顾性分析2015年1月至2016年2月在兰州大学第一医院神经内科住院的脑梗死患者458例。其中脑梗死合并颈动脉粥样硬化斑块组(斑块组)234例,脑梗死无颈动脉粥样硬化斑块组(无斑块组)224例。所有患者行颈动脉彩超检查明确有无斑块及斑块性质,行头颅CT或MRI检查明确脑梗死部位,并测定Hcy、UA、血脂、血糖等含量。研究结果:脑梗死合并颈动脉粥样硬化斑块组Hcy、UA水平高于脑梗死无颈动脉粥样硬化斑块组,差异有统计学意义(P0.01);脑梗死合并颈动脉粥样硬化斑块组患者中,不稳定斑块组Hcy、UA水平高于稳定斑块组,差异有统计学意义(P0.05)。研究结论:Hcy、UA水平可反映脑梗死合并颈动脉粥样硬化斑块组颈动脉斑块的性质,不稳定斑块组Hcy、UA水平较稳定斑块组高。Hcy、UA水平增高发生不稳斑块的风险越高,发生脑梗死的风险越大。早期筛查、控制Hcy、UA水平,定期监测颈动脉粥样硬化斑块并给予药物干预,对预防脑梗死发生具有临床指导意义。
[Abstract]:Objective: to study the relationship between the level of Hcysillurea and carotid atherosclerotic plaque in cerebral infarction and the relationship between the level of cystatin UA and the character of plaque in cerebral infarction complicated with carotid atherosclerotic plaque. Methods: a total of 458 patients with cerebral infarction were randomly selected and analyzed retrospectively from January 2015 to February 2016 in Department of Neurology, first Hospital of Lanzhou University. There were 234 cases of cerebral infarction complicated with carotid atherosclerotic plaque group (plaque group) and 224 cases of cerebral infarction without carotid atherosclerotic plaque group (no plaque group). All the patients were examined by carotid artery color Doppler ultrasound to determine the plaques and the nature of plaques, and the location of cerebral infarction was determined by CT or MRI, and the contents of HCI UAA, blood lipids and blood glucose were measured. The results showed that the level of Hcyn UA in cerebral infarction with carotid atherosclerotic plaque group was higher than that in cerebral infarction without carotid atherosclerotic plaque group, the difference was statistically significant (P 0.01), and in the cerebral infarction with carotid atherosclerotic plaque group, the patients with cerebral infarction and carotid atherosclerotic plaque group, The level of Hcyn UA in unstable plaque group was higher than that in stable plaque group, and the difference was statistically significant (P 0.05). Conclusion the results suggest that the level of HCI UA can reflect the nature of carotid plaques in patients with cerebral infarction and carotid atherosclerotic plaques. The higher the level of Hcyn UA in unstable plaques is, the higher the risk of developing unstable plaques is. The greater the risk of cerebral infarction. Early screening, controlling the level of cystatin UA, monitoring carotid atherosclerotic plaque regularly and giving drug intervention are of clinical significance in preventing cerebral infarction.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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