Wnt5a与神经胶质瘤关系的研究进展

发布时间：2018-04-27 22:17

本文选题：神经胶质瘤 + Wnta　；参考：《临床神经病学杂志》2017年02期

【摘要】：正神经胶质瘤是最常见的原发性颅内肿瘤,在恶性脑肿瘤中约占81%~([1]),WHO分级分为Ⅰ~Ⅳ级。传统治疗方式如手术、化疗、放疗等治疗效果难以使人满意。胶质母细胞瘤约占胶质瘤的45%,预后极差,手术后五年生存率不足5%~([1])。胶质瘤的发生发展与Wnt、Notch~([2])、Ras~([3])等多条信号通路的异常表达密切相关,近年来由Wnt5a所调控的Wnt信号通路在神经胶质瘤中的作用引起了广泛关注,为胶质瘤靶向治疗提供了新思路。
[Abstract]:Positive glioma is the most common primary intracranial tumor, accounting for 81% of malignant brain tumors. Traditional treatment methods such as surgery, chemotherapy, radiotherapy and other treatment results are not satisfactory. Glioblastoma accounts for about 45% of gliomas. The prognosis is very poor. The 5 year survival rate is less than 5% (1). The occurrence and development of glioma is closely related to the abnormal expression of many signal pathways, such as Wntttnntntchch ([2] Wnt5a ([3]) etc. In recent years, the role of Wnt signaling pathway regulated by Wnt5a in glioma has attracted wide attention, which provides a new idea for the targeted therapy of glioma.
【作者单位】：中国医科大学;中国医科大学科学实验中心;
【基金】：国家自然科学基金(81470758) 辽宁省“百万人才工程”资助项目(2011921039) 沈阳市科学计划项目大型仪器设备共享服务专项(F16-102-4-00)
【分类号】：R739.41

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