ApoE基因多态性对老年脑梗死患者颅内血管狭窄病理变化的影响

发布时间：2018-04-29 19:50

本文选题：载脂蛋白E + 基因多态性　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨载脂蛋白E(Apo E)基因多态性特点对血脂代谢和动脉粥样硬化(AS)性脑梗死患者颅内动脉硬化狭窄病理变化的影响。方法检测方法采用"基因芯片法(Gene Chip)",测定180例脑AS性脑梗死患者Apo E基因型,自动生化分析仪检测血脂水平,磁共振血管造影(MRA)检查测定分析颅内动脉硬化狭窄程度。结果 Apo E等位基因及频率:ε2 25.6%、ε3 65.6%、ε4 8.9%,基因型及频率:纯合子ε2/2 1.1%、ε3/3 62.2%、ε4/4 5.6%,杂合子ε2/3 24.4%、ε2/4 3.3%、ε3/4 1.1%。ε2组中高密度脂蛋白胆固醇(HDL-C)含量高于ε4组,ε4组中的胆固醇(TC)、低密度脂蛋白胆固醇(LDC-C)较ε2组、ε3组高(均P0.05);与ε3组相比,ε4组动脉硬化狭窄率较高,ε2组动脉硬化狭窄率较低(P0.05)。结论ε2可升高HDL-C水平,而ε4组中TC、LDL-C水平较高,ε4组中动脉硬化狭窄程度高于ε2组、ε3组,Apo E基因通过调节血脂代谢,进而影响颅内动脉血管AS狭窄发生发展,提示ε4是脑颅内AS脑梗死的危险遗传因素,ε2则是保护基因。
[Abstract]:Objective to investigate the effects of apolipoprotein (E(Apo) gene polymorphism on lipid metabolism and pathological changes of intracranial arteriosclerosis stenosis in patients with cerebral infarction caused by atherosclerosis. Methods Apo E genotypes were detected by gene chip method in 180 patients with as cerebral infarction. Blood lipid levels were detected by automatic biochemical analyzer, and the degree of intracranial arteriosclerosis stenosis was analyzed by magnetic resonance angiography (MRA). Results the alleles and frequencies of Apo E were 蔚 225.6, 蔚 365.6, 蔚 48.9. Genotype and frequency: homozygous 蔚 2 / 21.2, 蔚 4 / 45.6, heterozygote 蔚 2 / 3 24.4, 蔚 2 / 4 3.33, 蔚 3 / 4 1.1.The content of HDL-Con in 蔚 2 group was higher than that in 蔚 4 group. Compared with 蔚 3 group, the rate of atherosclerotic stenosis in 蔚 4 group was higher than that in 蔚 2 group, and that in 蔚 2 group was lower than that in 蔚 2 group. Conclusion 蔚 2 can increase the level of HDL-C, while the level of TCnLDL-C in 蔚 4 group is higher than that in 蔚 2 group, and the degree of atherosclerosis stenosis in 蔚 4 group is higher than that in 蔚 2 group. Apo E gene in 蔚 3 group affects the occurrence and development of as stenosis of intracranial artery by regulating the metabolism of blood lipids. The results suggest that 蔚 4 is a risk genetic factor for cerebral infarction in as and 蔚 2 is a protective gene.
【作者单位】：郑州大学第二附属医院老年医学科;
【基金】：河南省科技厅科技攻关项目(122102310603)
【分类号】：R743.3

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