颈动脉粥样硬化斑块及血清炎症因子与老年脑梗死发病的相关性分析

发布时间：2018-05-02 12:01

本文选题：脑梗死 + 颈动脉粥样硬化　；参考：《山东医药》2017年45期

【摘要】：目的探讨颈动脉粥样硬化斑块影像学特征及血清炎症因子与老年脑梗死发病的相关性。方法采用彩色多普勒超声检测的老年脑梗死患者100例,其中首发急性脑梗死患者50例(首发脑梗死组),继发性脑梗死患者50例(继发脑梗死组),分析患者颈动脉超声的特征及斑块性质。采用ELISA法检测脑梗死患者血清中脑钠肽(BNP)、脑钠肽前体(NT-pro BNP)、炎症小体3(NLPR3)、凝集素样氧化型低密度脂蛋白受体(LOX-1)、IL-1β水平。以本院同期健康体检者130例作为对照组。结果与对照组比较,老年脑梗死患者颈动脉内-中膜厚度、颈动脉内径、颈动脉管壁增厚比例和颈动脉内膜毛糙、回声增强比例高,颈动脉粥样斑块检出率高,血清中BNP、NT-pro BNP、NLPR3、LOX-1、IL-1β水平升高,动脉粥样硬化危险因素如高血压史、糖尿病史的发生率高,血清总胆固醇、甘油三酯、低密度脂蛋白水平高,高密度脂蛋白水平低(P均0.05)。首发与继发脑梗死组比较,P均0.05。结论颈动脉粥样硬化斑块影像学特征及血清炎症因子与老年脑梗死发病均有关。
[Abstract]:Objective to investigate the imaging features of carotid atherosclerotic plaque and the correlation between serum inflammatory factors and cerebral infarction in the elderly. Methods 100 elderly patients with cerebral infarction were examined by color Doppler ultrasound. Among them, 50 patients with initial acute cerebral infarction (first cerebral infarction group) and 50 patients with secondary cerebral infarction (secondary cerebral infarction group) were analyzed the characteristics of carotid artery ultrasound and plaque properties. The levels of BNPP, NT-pro BNPP, NLPR3, LOX-1 尾 in serum of patients with cerebral infarction were detected by ELISA method. 130 cases of health examination in the same period were taken as the control group. Results compared with the control group, the carotid artery intima-media thickness, carotid artery diameter, carotid wall thickening ratio, carotid intima roughness, echo enhancement ratio and carotid atherosclerotic plaque detection rate were higher in elderly patients with cerebral infarction. Serum BNPNT-pro BNPP NLPR3 LOX-1 尾 level increased, atherosclerosis risk factors such as hypertension history, diabetes history high incidence, serum total cholesterol, triglyceride, low density lipoprotein level, high density lipoprotein level low P 0.05. Compared with the primary cerebral infarction group, the P of the first episode group and the secondary cerebral infarction group were 0.05. Conclusion the imaging features of carotid atherosclerotic plaque and serum inflammatory factors are related to the incidence of cerebral infarction in the elderly.
【作者单位】：宿州市立医院;
【分类号】：R743.3

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