慢波睡眠与癫痫患者认知功能关系的研究进展

发布时间：2018-05-08 08:55

本文选题：癫痫 + 慢波睡眠　；参考：《山东医药》2017年28期

【摘要】：睡眠是维持正常人认知功能的重要条件。睡眠剥夺,特别是慢波睡眠剥夺,可导致正常人认知功能障碍,如学习记忆障碍。目前认为,慢波睡眠主要通过氧化应激激活以及改变神经递质分泌、海马区电活动、突触稳态等途径影响正常人的认知功能状态。认知功能障碍是癫痫患者常见的伴随症状之一,而癫痫患者中大部分存在睡眠结构紊乱,特别是慢波睡眠比例降低。因此,癫痫患者的认知功能状态亦可能与慢波睡眠有关,其机制可能与慢波睡眠时异常慢波放电导致大脑网络受抑制或中断有关。癫痫发作时常伴有异常慢波的出现,其异常放电激活大脑网络,导致患者出现认知功能障碍,而慢波睡眠异常亦可损害认知功能状态,目前对三者间的相互作用具体机制并不完全清楚,尚需进一步研究。
[Abstract]:Sleep is an important condition for maintaining normal cognitive function. Sleep deprivation, especially slow-wave sleep deprivation, can lead to cognitive impairment, such as learning and memory impairment. At present, it is believed that slow wave sleep affects the cognitive function of normal people through oxidative stress activation and changes in neurotransmitter secretion, hippocampal electrical activity and synaptic homeostasis. Cognitive dysfunction is one of the common concomitant symptoms in epileptic patients, and most of the epileptic patients have sleep structure disorder, especially slow wave sleep. Therefore, the cognitive state of epileptic patients may also be related to slow wave sleep, and its mechanism may be related to the inhibition or interruption of brain network caused by abnormal slow wave discharge during slow wave sleep. Epileptic seizures are often accompanied by abnormal slow waves, which activate the brain network and lead to cognitive dysfunction, and slow wave sleep disorders can also damage cognitive function. At present, the specific mechanism of the interaction between the three is not completely clear and needs further study.
【作者单位】：山东省千佛山医院;
【基金】：山东省医药卫生科技发展计划项目(2013WS0139)
【分类号】：R742.1

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