甘露醇与尼莫地平联合治疗高血压脑出血的疗效及对血流动力学的影响

发布时间：2018-05-13 21:50

本文选题：高血压脑出血 + 甘露醇　；参考：《中国医院用药评价与分析》2016年12期

【摘要】：目的:探讨甘露醇与尼莫地平联合治疗高血压脑出血的临床疗效及对血流动力学的影响。方法:选择2011年1月—2015年12月萍乡市第二人民医院收治的100例高血压脑出血患者,以随机数字表法分为对照组和观察组,每组各50例。对照组患者采用甘露醇静脉滴注治疗,观察组患者在对照组基础上加用尼莫地平治疗。比较2组患者临床治疗效果及治疗前后血流动力学参数变化情况。结果:观察组患者临床治疗总有效率为88%(44/50),显著高于对照组的70%(35/50),差异有统计学意义(P0.05)。治疗后,2组患者血肿体积和美国国立卫生研究院卒中量表评分均较治疗前明显降低,且观察组患者降低程度明显高于对照组,差异均有统计学意义(P0.05);2组患者血流量、血流速度、外周阻力和临界压力等血流动力学指标均较治疗前明显改善,且观察组患者改善程度明显高于对照组,差异均有统计学意义(P0.05)。结论:甘露醇与尼莫地平联合治疗高血压脑出血,疗效满意,血流动力学指标改善良好。
[Abstract]:Objective: to investigate the effect of mannitol and nimodipine on hypertensive intracerebral hemorrhage. Methods: 100 patients with hypertensive intracerebral hemorrhage admitted in Pingxiang second people's Hospital from January 2011 to December 2015 were divided into control group (n = 50) and observation group (n = 50). The patients in the control group were treated with mannitol intravenous drip, while the patients in the observation group were treated with nimodipine on the basis of the control group. To compare the effect of clinical treatment and the changes of hemodynamic parameters before and after treatment. Results: the total effective rate of clinical treatment in the observation group was 88 / 44 / 50, which was significantly higher than that in the control group (70 / 35 / 50), and the difference was statistically significant (P 0.05). After treatment, the hematoma volume and the stroke scale score of the National Institutes of Health in the two groups were significantly lower than those before treatment, and the degree of decrease in the observation group was significantly higher than that in the control group. The difference was statistically significant in the blood flow and blood flow velocity of the two groups. The hemodynamic indexes such as peripheral resistance and critical pressure were significantly improved compared with those before treatment, and the improvement degree of the patients in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). Conclusion: mannitol combined with nimodipine in the treatment of hypertensive intracerebral hemorrhage has satisfactory curative effect and good hemodynamic improvement.
【作者单位】：萍乡市第二人民医院脑外科;
【分类号】：R544.1;R743.34

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