长春西汀注射液对老年腔隙性脑梗死患者微循环和血液流变学的影响

发布时间：2018-05-15 04:06

本文选题：长春西汀 + 腔隙性脑梗死　；参考：《中国老年学杂志》2017年06期

【摘要】：目的探讨长春西汀注射液对老年腔隙性脑梗死患者微循环和血液流变学的影响。方法选择老年腔隙性脑梗死患者80例,按照随机数字表法分为对照组和观察组,各40例。两组患者均给予常规基础治疗,包括降压、降脂、降糖等,两组患者均口服拜阿司匹林、阿伐他汀钙。观察组在此基础上静点长春西汀注射液,每日1次,7 d为1个疗程,两组患者均治疗2个疗程。观察两组患者治疗前后血液流变学指标、炎性反应指标,采用积分评价两组患者治疗前后甲襞微循环指标(管袢形态、管袢流态、袢周状态)。结果治疗后,两组患者全血低切黏度、高切黏度、血浆黏度、红细胞聚集指数、血浆纤维蛋白原、血小板1 min聚集率、血小板3 min聚集率较治疗前均有显著改善(均P0.05),且观察组改善显著优于对照组(均P0.05)。治疗后,两组患者红细胞沉降率(ESR)、C反应蛋白(CRP)均较治疗前有所改善(P0.05),且观察组改善情况显著优于对照组(P0.05)。治疗后,两组患者管袢形态、管袢流态及袢周状态积分较治疗前均有所改善(P0.05),且观察组改善情况显著优于对照组(P0.05)。结论长春西汀注射液可以改善老年腔隙性梗死患者血液流变学和微循环状态,并具有一定抗感染作用。
[Abstract]:Objective to investigate the effect of vinpocetine injection on microcirculation and hemorheology in elderly patients with lacunar cerebral infarction. Methods 80 senile patients with lacunar infarction were randomly divided into control group and observation group with 40 cases each. Two groups of patients were given routine basic treatment, including hypotension, lipid-lowering, hypoglycemia and so on. Both groups were given orally Aspirin and Avastatin calcium. On this basis, the observation group received vinpocetine injection once a day for 7 days as a course of treatment, and both groups were treated for 2 courses. The hemorheology index and inflammatory reaction index were observed before and after treatment. The nailfold microcirculation indexes (shape of loop, flow state of loop and periloop) were evaluated by integral before and after treatment. Results after treatment, the whole blood low shear viscosity, high shear viscosity, plasma viscosity, erythrocyte aggregation index, plasma fibrinogen and platelet 1 min aggregation rate were observed in both groups. The platelet aggregation rate of 3 min was significantly improved compared with that before treatment (all P 0.05%), and the improvement of the observation group was significantly better than that of the control group (all P 0.05). After treatment, the erythrocyte sedimentation rate and the erythrocyte sedimentation rate of the two groups were improved compared with those before treatment, and the improvement of the observation group was significantly better than that of the control group. After treatment, the shape of the loop, the flow state of the loop and the integral of the periloop state of the two groups were improved compared with those before treatment, and the improvement of the observation group was significantly better than that of the control group (P 0.05). Conclusion vinpocetine injection can improve hemorheology and microcirculation in elderly patients with lacunar infarction and has anti-infection effect.
【作者单位】：平湖市第二人民医院中西医结合内科;平湖市第二人民医院内一科;
【分类号】：R743.33

【参考文献】