脑卒中高危人群幽门螺杆菌感染对AIP、血脂异常的影响

发布时间：2018-05-15 05:07

本文选题：脑卒中 + 幽门螺杆菌　；参考：《中国动脉硬化杂志》2017年08期

【摘要】：目的探讨脑卒中高危人群幽门螺杆菌(Hp)感染与血脂水平及促动脉硬化指数(AIP)的关系,为其血脂紊乱及动脉粥样硬化的防治提供新思路。方法连续性选择2014年6月至2015年1月皖北煤电集团总医院体检中心体检者2872例,收集其临床资料,筛选出脑卒中高危人群371例,采用14C尿素呼气试验检测Hp感染情况,同时采用酶联免疫吸附法测定血清氧化型低密度脂蛋白(ox-LDL)水平,分析Hp感染与总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、ox-LDL及AIP之间的关系。结果 Hp感染者155例(41.8%,155/371),Hp感染组血清TC、TG、LDLC、ox-LDL、AIP水平明显高于非HP感染组(P0.05)。多元线性回归分析显示,Hp感染与AIP水平呈正相关。结论 Hp感染可能在一定程度上引起脑卒中高危人群脂质代谢紊乱,导致AIP水平增高,促进动脉粥样硬化的进展。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (HP) infection and blood lipid levels and AIPs in high risk population of stroke, and to provide a new idea for the prevention and treatment of hyperlipidemia and atherosclerosis. Methods from June 2014 to January 2015, 2872 patients were selected from the physical examination center of Wanbei Coal Power Group General Hospital. Their clinical data were collected, 371 patients with high risk of stroke were selected, and HP infection was detected by 14C urea breath test (14C urea breath test). The serum levels of oxidized low density lipoprotein (ox-LDL) were determined by enzyme-linked immunosorbent assay (Elisa), and the relationship between HP infection and total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDL-C) and AIP were analyzed. Results the AIP level in 155 cases of HP infection was significantly higher than that in non-HP infection group (P 0.05). Multiple linear regression analysis showed that HP infection was positively correlated with AIP level. Conclusion HP infection may lead to the disorder of lipid metabolism in the high risk population of stroke to some extent, lead to the increase of AIP level and promote the progression of atherosclerosis.
【作者单位】：皖北煤电集团总医院蚌埠医学院第三附属医院神经内科;皖北煤电集团总医院蚌埠医学院第三附属医院药剂科;
【分类号】：R743.3

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