缺血性卒中患者椎动脉颅内段钙化影响因素分析

发布时间：2018-05-17 10:30

本文选题：椎动脉颅内段钙化 + 影响因素　；参考：《浙江大学》2016年硕士论文

【摘要】：目的：探讨急性缺血性卒中患者椎动脉颅内段钙化的影响因素。方法：收集2013年11月—2015年6月浙江大学附属第一医院神经内科住院的诊断为急性缺血性卒中患者共185例,分为椎动脉颅内段钙化组(44例)和椎动脉颅内段非钙化组(141例),回顾性分析两组患者的临床资料咆括性别、年龄、高血压、糖尿病、吸烟、饮酒等],实验室检查、影像学表现等差异。结果：(1)钙化组平均年龄(69.86±9.6)岁,非钙化组平均年龄(63.55±11.22)岁,两者间存在显著差异(p0.001)。钙化组高血压患者39例(88.6%),非高血压患者5例(11.4%),非钙化组高血压患者85例(60.3%),非高血压患者56例(39.7%),两者间存在显著差异(p0.001)；将颈内动脉钙化程度按钙化分数分为严重钙化(3-4分)与非严重钙化(0-2分),椎动脉颅内段钙化组颈内动脉严重钙化22例(50%),椎动脉无钙化组颈内动脉严重钙化21例(14.9%),两者间存在显著差异(p0.001)；(2)钙化组碱性磷酸酶水平为68.63±17.76,非钙化组为79.42±31.03,两者间存在显著差异(p=0.006)；(3)钙化组饮酒14例(31.8%),从未饮酒30例(68.1%),非钙化组饮酒67例(47.5%),从未饮酒74例(52.4%),两者存在差异但不具有统计学意义(p=0.067)；钙化组HDL-C为1.33±1.80mmol/L,非钙化组为1.05±0.31；钙化组TT3为1.49±0.33,非钙化组为1.40±0.25,钙化组两种指标均偏高,但差异不具有统计学意义(p值分别为0.079、0.093)；(4)椎动脉颅内段钙化易累及优势椎,左椎钙化多见；结论：急性缺血性卒中患者椎动脉颅内段钙化独立危险因素包括年龄、高血压、颈内动脉颅内段严重钙化；碱性磷酸酶或存在保护机制。优势椎更易发生钙化,左椎多见。
[Abstract]:Objective: to investigate the influencing factors of intracranial calcification of vertebral artery in patients with acute ischemic stroke. Methods: from November 2013 to June 2015, 185 patients with acute ischemic stroke in Department of Neurology, the first affiliated Hospital of Zhejiang University, were collected. The clinical data of the two groups were retrospectively analyzed, including sex, age, hypertension, diabetes, smoking, drinking, etc. Imaging findings were different. Results the average age of the calcified group was 69.86 卤9.6 years old, and that of the non-calcified group was 63.55 卤11.22 years old. There was a significant difference between the two groups (p 0.001). The calcification degree of internal carotid artery was divided into severe calcium by calcification group (n = 85), hypertension group (n = 85), and non-hypertension group (n = 56), with significant difference (p 0.001). There were significant differences between the internal carotid artery calcification group (n = 22) and the non-severe calcification group (n = 22), the internal carotid artery calcification group (n = 22) and the internal carotid artery calcification group (n = 21). There was a significant difference between them (p 0.001 / 2) the alkaline phosphatase water (ALP) water in the calcified group was significantly different from that in the non-calcified group (n = 21). The average was 68.63 卤17.76, and the non-calcification group was 79.42 卤31.03. There was a significant difference between the two groups. There were 14 cases of alcohol consumption in calcified group, 30 cases of never drinking alcohol, 67 cases of non-calcified group and 67 cases of non-calcification group. There was no significant difference between the two groups, but there was no statistical significance between the two groups in HDL-C. The TT3 of non-calcified group was 1.49 卤0.33, and that of non-calcified group was 1.40 卤0.25. The two indexes of calcification group were higher than that of non-calcification group, and the TT3 of calcification group was 1.49 卤0.33, 1.40 卤0.25, respectively, and that of non-calcification group was 1.33 卤1.80 mmol / L and 1.05 卤0.31, respectively. However, the difference was not statistically significant (P = 0.079 ~ 0.093). The intracranial segment calcification of vertebral artery is more likely to involve the dominant vertebrae and the left vertebra calcification is more common. Conclusion: the independent risk factors of intracranial artery calcification in patients with acute ischemic stroke include age, hypertension, and hypertension. Severe calcification of the intracranial segment of the internal carotid artery; alkaline phosphatase may have a protective mechanism. The dominant vertebrae are more prone to calcification, and the left vertebrae are more common.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R743.3

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